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@ARTICLE{Wormuth:271084,
      author       = {Wormuth, Carola and Papazoglou, Anna and Henseler,
                      Christina and Ehninger, Dan and Broich, Karl and Haenisch,
                      Britta and Hescheler, Jürgen and Köhling, Rüdiger and
                      Weiergräber, Marco},
      title        = {{A} {N}ovel {R}at {I}nfant {M}odel of {M}edial {T}emporal
                      {L}obe {E}pilepsy {R}eveals {N}ew {I}nsight into the
                      {M}olecular {B}iology and {E}pileptogenesis in the
                      {D}eveloping {B}rain.},
      journal      = {Neural plasticity},
      volume       = {2024},
      number       = {1},
      issn         = {2090-5904},
      address      = {New York, NY},
      publisher    = {Hindawi},
      reportid     = {DZNE-2024-00956},
      pages        = {9946769},
      year         = {2024},
      abstract     = {Although several adult rat models of medial temporal lobe
                      epilepsy (mTLE) have been described in detail, our knowledge
                      of mTLE epileptogenesis in infant rats is limited. Here, we
                      present a novel infant rat model of mTLE (InfRPil-mTLE)
                      based on a repetitive, triphasic injection regimen
                      consisting of low-dose pilocarpine administrations (180
                      mg/kg. i.p.) on days 9, 11, and 15 post partum (pp). The
                      model had a survival rate of $>80\%$ and exhibited
                      characteristic spontaneous recurrent electrographic seizures
                      (SRES) in both the hippocampus and cortex that persisted
                      into adulthood. Using implantable video-EEG radiotelemetry,
                      we quantified a complex set of seizure parameters that
                      demonstrated the induction of chronic
                      electroencephalographic seizure activity in our InfRPil-mTLE
                      model, which predominated during the dark cycle. We further
                      analyzed selected candidate genes potentially relevant to
                      epileptogenesis using a RT-qPCR approach. Several
                      candidates, such as the low-voltage-activated Ca2+ channel
                      Cav3.2 and the auxiliary subunits β 1 and β 2, which were
                      previously reported to be upregulated in the hippocampus of
                      the adult pilocarpine mTLE model, were found to be
                      downregulated (together with Cav2.1, Cav2.3, M1, and M3) in
                      the hippocampus and cortex of our InfRPil-mTLE model. From a
                      translational point of view, our model could serve as a
                      blueprint for childhood epileptic disorders and further
                      contribute to antiepileptic drug research and development in
                      the future.},
      keywords     = {Animals / Epilepsy, Temporal Lobe: physiopathology /
                      Epilepsy, Temporal Lobe: genetics / Epilepsy, Temporal Lobe:
                      metabolism / Epilepsy, Temporal Lobe: chemically induced /
                      Disease Models, Animal / Rats / Pilocarpine /
                      Electroencephalography / Hippocampus: metabolism / Animals,
                      Newborn / Brain: metabolism / Rats, Sprague-Dawley / Male /
                      Female / Pilocarpine (NLM Chemicals)},
      cin          = {AG Ehninger / AG Hänisch},
      ddc          = {610},
      cid          = {I:(DE-2719)1013005 / I:(DE-2719)1013010},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 354 - Disease
                      Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39104708},
      pmc          = {pmc:PMC11300100},
      doi          = {10.1155/2024/9946769},
      url          = {https://pub.dzne.de/record/271084},
}