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@MISC{Dehestani:271085,
      author       = {Dehestani, Mohammad and Kozareva, V. and Blauwendraat,
                      Cornelis and Fränkel, E. and Gasser, Thomas and Bansal,
                      Vikas},
      title        = {{D}ataset: {T}ranscriptomic changes in oligodendrocytes and
                      precursor cells predicts clinical outcomes of {P}arkinson's
                      disease},
      publisher    = {Gene Expression Omnibus},
      reportid     = {DZNE-2024-00957},
      year         = {2024},
      abstract     = {Several prior studies have proposed the involvement of
                      various brain regions and cell types in Parkinson's disease
                      (PD) pathology. Here, we performed snRNA-seq on the
                      prefrontal cortex and anterior cingulate regions from
                      post-mortem control and PD brain tissue. We found a
                      significant association of oligodendrocytes (ODCs) and
                      oligodendrocyte precursor cells (OPCs) with PD-linked risk
                      loci and report several dysregulated genes and pathways,
                      including regulation of tau-protein kinase activity,
                      regulation of inclusion body assembly and protein processing
                      involved in protein targeting to mitochondria. In an
                      independent PD cohort with clinical measures (681 cases and
                      549 controls), polygenic risk scores derived from the
                      dysregulated genes significantly predicted Montreal
                      Cognitive Assessment (MoCA)-, and Beck Depression
                      Inventory-II (BDI-II)-scores but not motor impairment
                      (UPDRS-III). We extended our analysis of clinical outcome
                      prediction by incorporating three separate datasets that
                      were previously published by different laboratories. In the
                      first dataset from the anterior cingulate cortex, we
                      identified a correlation between ODCs and BDI-II. In the
                      second dataset obtained from the substantia nigra (SN), OPCs
                      displayed notable predictive ability for UPDRS-III. In the
                      third dataset from the SN region, a distinct subtype of
                      OPCs, labeled $OPC_ADM,$ exhibited predictive ability for
                      UPDRS-III. Intriguingly, the $OPC_ADM$ cluster also
                      demonstrated a significant increase in PD samples. These
                      results suggest that by expanding our focus to glial cells,
                      we can uncover region-specific molecular pathways associated
                      with PD symptoms.},
      cin          = {AG Bansal / AG Gasser},
      cid          = {I:(DE-2719)1210013 / I:(DE-2719)1210000},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 353
                      - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/271085},
}