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@ARTICLE{Dowling:271135,
      author       = {Dowling, Paul and Gargan, Stephen and Zweyer, Margit and
                      Henry, Michael and Meleady, Paula and Swandulla, Dieter and
                      Ohlendieck, Kay},
      title        = {{P}roteomic reference map for sarcopenia research: mass
                      spectrometric identification of key muscle proteins located
                      in the sarcomere, cytoskeleton and the extracellular
                      matrix.},
      journal      = {European journal of translational myology},
      volume       = {34},
      number       = {2},
      issn         = {2037-7452},
      address      = {Padova},
      publisher    = {Unipress},
      reportid     = {DZNE-2024-01003},
      pages        = {12564},
      year         = {2024},
      abstract     = {Sarcopenia of old age is characterized by the progressive
                      loss of skeletal muscle mass and concomitant decrease in
                      contractile strength. Age-related skeletal muscle
                      dysfunctions play a key pathophysiological role in the
                      frailty syndrome and can result in a drastically diminished
                      quality of life in the elderly. Here we have used mass
                      spectrometric analysis of the mouse hindlimb musculature to
                      establish the muscle protein constellation at advanced age
                      of a widely used sarcopenic animal model. Proteomic results
                      were further analyzed by systems bioinformatics of voluntary
                      muscles. In this report, the proteomic survey of aged
                      muscles has focused on the expression patterns of proteins
                      involved in the contraction-relaxation cycle, membrane
                      cytoskeletal maintenance and the formation of the
                      extracellular matrix. This includes proteomic markers of the
                      fast versus slow phenotypes of myosin-containing thick
                      filaments and actin-containing thin filaments, as well as
                      proteins that are associated with the non-sarcomeric
                      cytoskeleton and various matrisomal layers. The
                      bioanalytical usefulness of the newly established reference
                      map was demonstrated by the comparative screening of normal
                      versus dystrophic muscles of old age, and findings were
                      verified by immunoblot analysis.},
      cin          = {AG Sabir},
      ddc          = {610},
      cid          = {I:(DE-2719)5000032},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38787300},
      pmc          = {pmc:PMC11264229},
      doi          = {10.4081/ejtm.2024.12564},
      url          = {https://pub.dzne.de/record/271135},
}