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000271136 1001_ $$aDowling, Paul$$b0
000271136 245__ $$aProteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins of organelles, cellular signaling, bioenergetic metabolism and molecular chaperoning.
000271136 260__ $$aPadova$$bUnipress$$c2024
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000271136 520__ $$aDuring the natural aging process, frailty is often associated with abnormal muscular performance. Although inter-individual differences exit, in most elderly the tissue mass and physiological functionality of voluntary muscles drastically decreases. In order to study age-related contractile decline, animal model research is of central importance in the field of biogerontology. Here we have analyzed wild type mouse muscle to establish a proteomic map of crude tissue extracts. Proteomics is an advanced and large-scale biochemical method that attempts to identify all accessible proteins in a given biological sample. It is a technology-driven approach that uses mass spectrometry for the characterization of individual protein species. Total protein extracts were used in this study in order to minimize the potential introduction of artefacts due to excess subcellular fractionation procedures. In this report, the proteomic survey of aged muscles has focused on organellar marker proteins, as well as proteins that are involved in cellular signaling, the regulation of ion homeostasis, bioenergetic metabolism and molecular chaperoning. Hence, this study has establish a proteomic reference map of a highly suitable model system for future aging research.
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000271136 7001_ $$aGargan, Stephen$$b1
000271136 7001_ $$0P:(DE-2719)9000835$$aZweyer, Margit$$b2$$udzne
000271136 7001_ $$aHenry, Michael$$b3
000271136 7001_ $$aMeleady, Paula$$b4
000271136 7001_ $$aSwandulla, Dieter$$b5
000271136 7001_ $$aOhlendieck, Kay$$b6
000271136 773__ $$0PERI:(DE-600)2545577-1$$a10.4081/ejtm.2024.12565$$gVol. 34, no. 2$$n2$$p12565$$tEuropean journal of translational myology$$v34$$x2037-7452$$y2024
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