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@ARTICLE{Dowling:271136,
      author       = {Dowling, Paul and Gargan, Stephen and Zweyer, Margit and
                      Henry, Michael and Meleady, Paula and Swandulla, Dieter and
                      Ohlendieck, Kay},
      title        = {{P}roteomic reference map for sarcopenia research: mass
                      spectrometric identification of key muscle proteins of
                      organelles, cellular signaling, bioenergetic metabolism and
                      molecular chaperoning.},
      journal      = {European journal of translational myology},
      volume       = {34},
      number       = {2},
      issn         = {2037-7452},
      address      = {Padova},
      publisher    = {Unipress},
      reportid     = {DZNE-2024-01004},
      pages        = {12565},
      year         = {2024},
      abstract     = {During the natural aging process, frailty is often
                      associated with abnormal muscular performance. Although
                      inter-individual differences exit, in most elderly the
                      tissue mass and physiological functionality of voluntary
                      muscles drastically decreases. In order to study age-related
                      contractile decline, animal model research is of central
                      importance in the field of biogerontology. Here we have
                      analyzed wild type mouse muscle to establish a proteomic map
                      of crude tissue extracts. Proteomics is an advanced and
                      large-scale biochemical method that attempts to identify all
                      accessible proteins in a given biological sample. It is a
                      technology-driven approach that uses mass spectrometry for
                      the characterization of individual protein species. Total
                      protein extracts were used in this study in order to
                      minimize the potential introduction of artefacts due to
                      excess subcellular fractionation procedures. In this report,
                      the proteomic survey of aged muscles has focused on
                      organellar marker proteins, as well as proteins that are
                      involved in cellular signaling, the regulation of ion
                      homeostasis, bioenergetic metabolism and molecular
                      chaperoning. Hence, this study has establish a proteomic
                      reference map of a highly suitable model system for future
                      aging research.},
      cin          = {AG Sabir},
      ddc          = {610},
      cid          = {I:(DE-2719)5000032},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38787292},
      pmc          = {pmc:PMC11264233},
      doi          = {10.4081/ejtm.2024.12565},
      url          = {https://pub.dzne.de/record/271136},
}