%0 Journal Article
%A Garzone, David
%A Imtiaz, Mohammed Aslam
%A Mauschitz, Matthias M
%A Aziz, N. Ahmad
%A Holz, Frank G
%A Breteler, Monique
%A Finger, Robert P
%T Age-Related Macular Degeneration and Its Genetic Risk: A Population-based Study.
%J Current eye research
%V 50
%N 1
%@ 0271-3683
%C Abingdon
%I Taylor & Francis Group
%M DZNE-2024-01053
%P 82 - 86
%D 2025
%X Specific genetic factors might serve as markers for risk stratification of AMD progression, but their association with key features of AMD has not been fully elucidated. Thus, we investigated the association between overall and pathway-specific genetic risk scores (GRS) and lead loci (ARMS2, CFH) with AMD stages and features of high-risk nonlate AMD, including reticular pseudodrusen (RPD) and large drusen area (LDA).We performed a cross-sectional analysis of data from the Rhineland Study, a population-based study in Bonn, Germany. We included 4016 individuals aged 50 years and older of European descent. GRS and pathway-specific subscores were constructed based on a large genome-wide association study of AMD. Subscores were generated based on gene-pathways associations (complement, extracellular matrix remodeling (ECM) and lipid metabolism). Associations were assessed using logistic and multinomial regression.The mean age of participants was 63.36 years and 1813 (45.1
%K Humans
%K Male
%K Female
%K Cross-Sectional Studies
%K Middle Aged
%K Macular Degeneration: genetics
%K Macular Degeneration: epidemiology
%K Aged
%K Genetic Predisposition to Disease
%K Genome-Wide Association Study
%K Risk Factors
%K Germany: epidemiology
%K Complement Factor H: genetics
%K Polymorphism, Single Nucleotide
%K Retinal Drusen: genetics
%K Retinal Drusen: epidemiology
%K Proteins: genetics
%K Population Surveillance
%K Disease Progression
%K AMD (Other)
%K PRS (Other)
%K RPD (Other)
%K genetics (Other)
%K retina (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39155542
%R 10.1080/02713683.2024.2388692
%U https://pub.dzne.de/record/271698