TY  - JOUR
AU  - Garzone, David
AU  - Imtiaz, Mohammed Aslam
AU  - Mauschitz, Matthias M
AU  - Aziz, N. Ahmad
AU  - Holz, Frank G
AU  - Breteler, Monique
AU  - Finger, Robert P
TI  - Age-Related Macular Degeneration and Its Genetic Risk: A Population-based Study.
JO  - Current eye research
VL  - 50
IS  - 1
SN  - 0271-3683
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - DZNE-2024-01053
SP  - 82 - 86
PY  - 2025
AB  - Specific genetic factors might serve as markers for risk stratification of AMD progression, but their association with key features of AMD has not been fully elucidated. Thus, we investigated the association between overall and pathway-specific genetic risk scores (GRS) and lead loci (ARMS2, CFH) with AMD stages and features of high-risk nonlate AMD, including reticular pseudodrusen (RPD) and large drusen area (LDA).We performed a cross-sectional analysis of data from the Rhineland Study, a population-based study in Bonn, Germany. We included 4016 individuals aged 50 years and older of European descent. GRS and pathway-specific subscores were constructed based on a large genome-wide association study of AMD. Subscores were generated based on gene-pathways associations (complement, extracellular matrix remodeling (ECM) and lipid metabolism). Associations were assessed using logistic and multinomial regression.The mean age of participants was 63.36 years and 1813 (45.1
KW  - Humans
KW  - Male
KW  - Female
KW  - Cross-Sectional Studies
KW  - Middle Aged
KW  - Macular Degeneration: genetics
KW  - Macular Degeneration: epidemiology
KW  - Aged
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Risk Factors
KW  - Germany: epidemiology
KW  - Complement Factor H: genetics
KW  - Polymorphism, Single Nucleotide
KW  - Retinal Drusen: genetics
KW  - Retinal Drusen: epidemiology
KW  - Proteins: genetics
KW  - Population Surveillance
KW  - Disease Progression
KW  - AMD (Other)
KW  - PRS (Other)
KW  - RPD (Other)
KW  - genetics (Other)
KW  - retina (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39155542
DO  - DOI:10.1080/02713683.2024.2388692
UR  - https://pub.dzne.de/record/271698
ER  -