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000271706 037__ $$aDZNE-2024-01058
000271706 041__ $$aEnglish
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000271706 1001_ $$aLevites, Yona$$b0
000271706 245__ $$aIntegrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease.
000271706 260__ $$aMaryland Heights, MO$$bElsevier$$c2024
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000271706 520__ $$aAlzheimer's disease (AD) is a complex neurodegenerative disorder that develops over decades. AD brain proteomics reveals vast alterations in protein levels and numerous altered biologic pathways. Here, we compare AD brain proteome and network changes with the brain proteomes of amyloid β (Aβ)-depositing mice to identify conserved and divergent protein networks with the conserved networks identifying an Aβ amyloid responsome. Proteins in the most conserved network (M42) accumulate in plaques, cerebrovascular amyloid (CAA), and/or dystrophic neuronal processes, and overexpression of two M42 proteins, midkine (Mdk) and pleiotrophin (PTN), increases the accumulation of Aβ in plaques and CAA. M42 proteins bind amyloid fibrils in vitro, and MDK and PTN co-accumulate with cardiac transthyretin amyloid. M42 proteins appear intimately linked to amyloid deposition and can regulate amyloid deposition, suggesting that they are pathology modifiers and thus putative therapeutic targets. We posit that amyloid-scaffolded accumulation of numerous M42+ proteins is a central mechanism mediating downstream pathophysiology in AD.
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000271706 650_7 $$2Other$$aAlzheimer’s disease
000271706 650_7 $$2Other$$aMidkine
000271706 650_7 $$2Other$$aPleiotrophin
000271706 650_7 $$2Other$$aaggregation
000271706 650_7 $$2Other$$aamyloid
000271706 650_7 $$2Other$$aanimal models
000271706 650_7 $$2Other$$aplaques
000271706 650_7 $$2Other$$aproteomics
000271706 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000271706 650_7 $$2NLM Chemicals$$aProteome
000271706 650_7 $$0134034-50-7$$2NLM Chemicals$$apleiotrophin
000271706 650_7 $$2NLM Chemicals$$aCarrier Proteins
000271706 650_7 $$2NLM Chemicals$$aCytokines
000271706 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000271706 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000271706 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000271706 650_2 $$2MeSH$$aProteomics: methods
000271706 650_2 $$2MeSH$$aAnimals
000271706 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000271706 650_2 $$2MeSH$$aHumans
000271706 650_2 $$2MeSH$$aPlaque, Amyloid: metabolism
000271706 650_2 $$2MeSH$$aPlaque, Amyloid: pathology
000271706 650_2 $$2MeSH$$aMice
000271706 650_2 $$2MeSH$$aBrain: metabolism
000271706 650_2 $$2MeSH$$aBrain: pathology
000271706 650_2 $$2MeSH$$aProteome: metabolism
000271706 650_2 $$2MeSH$$aMice, Transgenic
000271706 650_2 $$2MeSH$$aCarrier Proteins: metabolism
000271706 650_2 $$2MeSH$$aCarrier Proteins: genetics
000271706 650_2 $$2MeSH$$aCytokines: metabolism
000271706 650_2 $$2MeSH$$aMale
000271706 7001_ $$aDammer, Eric B$$b1
000271706 7001_ $$aRan, Yong$$b2
000271706 7001_ $$aTsering, Wangchen$$b3
000271706 7001_ $$aDuong, Duc$$b4
000271706 7001_ $$aAbreha, Measho$$b5
000271706 7001_ $$aGadhavi, Joshna$$b6
000271706 7001_ $$aLolo, Kiara$$b7
000271706 7001_ $$aTrejo-Lopez, Jorge$$b8
000271706 7001_ $$aPhillips, Jennifer$$b9
000271706 7001_ $$aIturbe, Andrea$$b10
000271706 7001_ $$aErquizi, Aya$$b11
000271706 7001_ $$aMoore, Brenda D$$b12
000271706 7001_ $$aRyu, Danny$$b13
000271706 7001_ $$aNatu, Aditya$$b14
000271706 7001_ $$aDillon, Kristy$$b15
000271706 7001_ $$aTorrellas, Jose$$b16
000271706 7001_ $$aMoran, Corey$$b17
000271706 7001_ $$aLadd, Thomas$$b18
000271706 7001_ $$aAfroz, Farhana$$b19
000271706 7001_ $$aIslam, Tariful$$b20
000271706 7001_ $$aJagirdar, Jaishree$$b21
000271706 7001_ $$aFunk, Cory C$$b22
000271706 7001_ $$aRobinson, Max$$b23
000271706 7001_ $$aRangaraju, Srikant$$b24
000271706 7001_ $$aBorchelt, David R$$b25
000271706 7001_ $$aErtekin-Taner, Nilüfer$$b26
000271706 7001_ $$aKelly, Jeffrey W$$b27
000271706 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b28$$udzne
000271706 7001_ $$aJohnson, Erik C B$$b29
000271706 7001_ $$aMcFarland, Karen$$b30
000271706 7001_ $$aLevey, Allan I$$b31
000271706 7001_ $$aProkop, Stefan$$b32
000271706 7001_ $$aSeyfried, Nicholas T$$b33
000271706 7001_ $$aGolde, Todd E$$b34
000271706 773__ $$0PERI:(DE-600)3019420-9$$a10.1016/j.xcrm.2024.101669$$gVol. 5, no. 8, p. 101669 -$$n8$$p101669$$tCell reports / Medicine$$v5$$x2666-3791$$y2024
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