Home > Publications Database > Innate immune memory after brain injury drives inflammatory cardiac dysfunction. > print

001     271707
005     20240908004702.0
024 7 _ |a 10.1016/j.cell.2024.06.028
|2 doi
024 7 _ |a pmid:39043180
|2 pmid
024 7 _ |a 0092-8674
|2 ISSN
024 7 _ |a 1097-4172
|2 ISSN
024 7 _ |a altmetric:165582787
|2 altmetric
037 _ _ |a DZNE-2024-01059
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Simats, Alba
|b 0
245 _ _ |a Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
260 _ _ |a New York, NY
|c 2024
|b Elsevier
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1725271234_24698
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic effects post-stroke on systemic immunity are underexplored. Here, we identify myeloid innate immune memory as a cause of remote organ dysfunction after stroke. Single-cell sequencing revealed persistent pro-inflammatory changes in monocytes/macrophages in multiple organs up to 3 months after brain injury, notably in the heart, leading to cardiac fibrosis and dysfunction in both mice and stroke patients. IL-1β was identified as a key driver of epigenetic changes in innate immune memory. These changes could be transplanted to naive mice, inducing cardiac dysfunction. By neutralizing post-stroke IL-1β or blocking pro-inflammatory monocyte trafficking with a CCR2/5 inhibitor, we prevented post-stroke cardiac dysfunction. Such immune-targeted therapies could potentially prevent various IL-1β-mediated comorbidities, offering a framework for secondary prevention immunotherapy.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 1
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a brain ischemia
|2 Other
650 _ 7 |a cardiac fibrosis
|2 Other
650 _ 7 |a cenicriviroc
|2 Other
650 _ 7 |a innate immune memory
|2 Other
650 _ 7 |a interleukin-1
|2 Other
650 _ 7 |a myeloid cells
|2 Other
650 _ 7 |a stroke
|2 Other
650 _ 7 |a systemic inflammation
|2 Other
650 _ 7 |a trained immunity
|2 Other
650 _ 7 |a Interleukin-1beta
|2 NLM Chemicals
650 _ 7 |a Receptors, CCR2
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Immunity, Innate
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Interleukin-1beta: metabolism
|2 MeSH
650 _ 2 |a Brain Injuries: immunology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Monocytes: metabolism
|2 MeSH
650 _ 2 |a Monocytes: immunology
|2 MeSH
650 _ 2 |a Immunologic Memory
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Inflammation: immunology
|2 MeSH
650 _ 2 |a Macrophages: immunology
|2 MeSH
650 _ 2 |a Macrophages: metabolism
|2 MeSH
650 _ 2 |a Stroke: complications
|2 MeSH
650 _ 2 |a Stroke: immunology
|2 MeSH
650 _ 2 |a Heart Diseases: immunology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Receptors, CCR2: metabolism
|2 MeSH
650 _ 2 |a Fibrosis
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Trained Immunity
|2 MeSH
700 1 _ |a Zhang, Sijia
|b 1
700 1 _ |a Messerer, Denise
|b 2
700 1 _ |a Chong, Faye
|b 3
700 1 _ |a Beşkardeş, Sude
|b 4
700 1 _ |a Chivukula, Aparna Sharma
|b 5
700 1 _ |a Cao, Jiayu
|b 6
700 1 _ |a Besson-Girard, Simon
|b 7
700 1 _ |a Montellano, Felipe A
|b 8
700 1 _ |a Morbach, Caroline
|b 9
700 1 _ |a Carofiglio, Olga
|b 10
700 1 _ |a Ricci, Alessio
|b 11
700 1 _ |a Roth, Stefan
|b 12
700 1 _ |a Llovera, Gemma
|b 13
700 1 _ |a Singh, Rashween
|0 P:(DE-2719)9001810
|b 14
|u dzne
700 1 _ |a Chen, Yiming
|b 15
700 1 _ |a Filser, Severin
|0 P:(DE-2719)2810523
|b 16
|u dzne
700 1 _ |a Plesnila, Nikolaus
|0 P:(DE-2719)9000853
|b 17
700 1 _ |a Braun, Christian
|b 18
700 1 _ |a Spitzer, Hannah
|b 19
700 1 _ |a Gokce, Ozgun
|0 P:(DE-2719)9002754
|b 20
|u dzne
700 1 _ |a Dichgans, Martin
|0 P:(DE-2719)2000030
|b 21
|u dzne
700 1 _ |a Heuschmann, Peter U
|b 22
700 1 _ |a Hatakeyama, Kinta
|b 23
700 1 _ |a Beltrán, Eduardo
|b 24
700 1 _ |a Clauss, Sebastian
|b 25
700 1 _ |a Bonev, Boyan
|b 26
700 1 _ |a Schulz, Christian
|b 27
700 1 _ |a Liesz, Arthur
|b 28
773 _ _ |a 10.1016/j.cell.2024.06.028
|g Vol. 187, no. 17, p. 4637 - 4655.e26
|0 PERI:(DE-600)2001951-8
|n 17
|p 4637 - 4655.e26
|t Cell
|v 187
|y 2024
|x 0092-8674
856 4 _ |u https://pub.dzne.de/record/271707/files/DZNE-2024-01059%20SUP.zip
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/271707/files/DZNE-2024-01059.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/271707/files/DZNE-2024-01059.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:271707
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 14
|6 P:(DE-2719)9001810
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 16
|6 P:(DE-2719)2810523
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 20
|6 P:(DE-2719)9002754
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 21
|6 P:(DE-2719)2000030
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Brain Function
|x 1
914 1 _ |y 2024
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-10-22
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CELL : 2022
|d 2023-10-22
915 _ _ |a Creative Commons Attribution-NonCommercial CC BY-NC 4.0
|0 LIC:(DE-HGF)CCBYNC4
|2 HGFVOC
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-10-22
915 _ _ |a IF >= 60
|0 StatID:(DE-HGF)9960
|2 StatID
|b CELL : 2022
|d 2023-10-22
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-10-22
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2023-10-22
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-10-22
920 1 _ |0 I:(DE-2719)5000022
|k AG Dichgans
|l Vascular Cognitive Impairment & Post-Stroke Dementia
|x 0
920 1 _ |0 I:(DE-2719)1013041
|k AG Gokce
|l Spatial Dynamics of Neurodegeneration
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)5000022
980 _ _ |a I:(DE-2719)1013041
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21