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000271866 0247_ $$2pmc$$apmc:PMC11350048
000271866 0247_ $$2doi$$a10.1002/alz.13909
000271866 0247_ $$2pmid$$apmid:38940303
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000271866 0247_ $$2ISSN$$a1552-5279
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000271866 037__ $$aDZNE-2024-01078
000271866 041__ $$aEnglish
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000271866 1001_ $$00000-0001-9326-8193$$aVogelgsang, Jonathan$$b0
000271866 245__ $$aPlasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease.
000271866 260__ $$aHoboken, NJ$$bWiley$$c2024
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000271866 520__ $$aBlood-based biomarkers are a cost-effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation-immunoassay (IP-IA) as a test for predicting cognitive decline.We measured levels of amyloid beta (Aβ)X-40 and AβX-42 in immunoprecipitated eluates from the DELCODE cohort. Receiver-operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by Aβ42/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia.We detected a significant correlation between AßX-42/X-40 in plasma and CSF (r = 0.473). Mixed-modeling analysis revealed a substantial prediction of AßX-42/X-40 with an area under the curve (AUC) of 0.81 for AP (sensitivity: 0.79, specificity: 0.74, positive predictive value [PPV]: 0.71, negative predictive value [NPV]: 0.81). In addition, lower AβX-42/X-40 ratios were associated with negative PACC5 slopes, suggesting cognitive decline.Our results suggest that assessing the plasma AβX-42/X-40 ratio via our semiautomated IP-IA is a promising biomarker when examining patients with early or preclinical AD.New plasma Aβ42/Aβ40 measurement using immunoprecipitation-immunoassay Plasma Aβ42/Aβ40 associated with longitudinal cognitive decline Promising biomarker to detect subjective cognitive decline at-risk for brain amyloid positivity.
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000271866 650_7 $$2Other$$aAlzheimer's disease
000271866 650_7 $$2Other$$aMCI
000271866 650_7 $$2Other$$aamyloid beta
000271866 650_7 $$2Other$$abiomarker
000271866 650_7 $$2Other$$adementia
000271866 650_7 $$2Other$$aplasma
000271866 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000271866 650_7 $$2NLM Chemicals$$aBiomarkers
000271866 650_7 $$2NLM Chemicals$$aPeptide Fragments
000271866 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-42)
000271866 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-40)
000271866 650_2 $$2MeSH$$aHumans
000271866 650_2 $$2MeSH$$aAmyloid beta-Peptides: blood
000271866 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000271866 650_2 $$2MeSH$$aAlzheimer Disease: blood
000271866 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000271866 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000271866 650_2 $$2MeSH$$aCognitive Dysfunction: blood
000271866 650_2 $$2MeSH$$aCognitive Dysfunction: cerebrospinal fluid
000271866 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000271866 650_2 $$2MeSH$$aMale
000271866 650_2 $$2MeSH$$aFemale
000271866 650_2 $$2MeSH$$aAged
000271866 650_2 $$2MeSH$$aBiomarkers: blood
000271866 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000271866 650_2 $$2MeSH$$aPeptide Fragments: blood
000271866 650_2 $$2MeSH$$aPeptide Fragments: cerebrospinal fluid
000271866 650_2 $$2MeSH$$aMiddle Aged
000271866 650_2 $$2MeSH$$aROC Curve
000271866 650_2 $$2MeSH$$aImmunoprecipitation
000271866 650_2 $$2MeSH$$aDisease Progression
000271866 7001_ $$aHansen, Niels$$b1
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000271866 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias$$b41$$udzne
000271866 7001_ $$0P:(DE-2719)2812865$$aSanzenbacher, Carolin$$b42$$udzne
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000271866 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b46$$udzne
000271866 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b47$$udzne
000271866 7001_ $$0P:(DE-2719)2811245$$aSchmid, Matthias$$b48$$udzne
000271866 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b49$$eLast author$$udzne
000271866 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13909$$gVol. 20, no. 8, p. 5132 - 5142$$n8$$p5132 - 5142$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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