000271880 001__ 271880
000271880 005__ 20240913103952.0
000271880 020__ $$a978-3-031-55528-2 (print)
000271880 020__ $$a978-3-031-55529-9 (electronic)
000271880 0247_ $$2doi$$a10.1007/978-3-031-55529-9_5
000271880 0247_ $$2pmid$$apmid:39207687
000271880 037__ $$aDZNE-2024-01092
000271880 041__ $$aEnglish
000271880 1001_ $$aCrockett, Alexis$$b0
000271880 245__ $$aProgress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease.
000271880 260__ $$aCham$$bSpringer International Publishing$$c2024
000271880 29510 $$aMicroglia / Tremblay, Marie-Ève (Editor) ; Cham : Springer International Publishing, 2024, Chapter 5 ; ISSN: 2190-5215=2190-5223 ; ISBN: 978-3-031-55528-2=978-3-031-55529-9 ; doi:10.1007/978-3-031-55529-9
000271880 300__ $$a65 - 80
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000271880 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1726216731_2424
000271880 4900_ $$aAdvances in Neurobiology$$v37
000271880 520__ $$aThe first line of defense for the central nervous system (CNS) against injury or disease is provided by microglia. Microglia were long believed to stay in a dormant/resting state, reacting only to injury or disease. This view changed dramatically with the development of modern imaging techniques that allowed the study of microglial behavior in the intact brain over time, to reveal the dynamic nature of their responses. Over the past two decades, in vivo imaging using multiphoton microscopy has revealed numerous new functions of microglia in the developing, adult, aged, injured, and diseased CNS. As the most dynamic cells in the brain, microglia continuously contact all structures and cell types, such as glial and vascular cells, neuronal cell bodies, axons, dendrites, and dendritic spines, and are believed to play a central role in sculpting neuronal networks throughout life. Following trauma, or in neurodegenerative or neuroinflammatory diseases, microglial responses range from protective to harmful, underscoring the need to better understand their diverse roles and states in different pathological conditions. In this chapter, we introduce multiphoton microscopy and discuss recent advances in structural and functional imaging technologies that have expanded our toolbox to study microglial states and behaviors in new ways and depths. We also discuss relevant mouse models available for in vivo imaging studies of microglia and review how such studies are constantly refining our understanding of the multifaceted role of microglia in the healthy and diseased CNS.
000271880 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
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000271880 650_7 $$2Other$$aAlzheimer’s disease
000271880 650_7 $$2Other$$aImaging technologies and methods
000271880 650_7 $$2Other$$aIn vitro experiments
000271880 650_7 $$2Other$$aIn vivo imaging
000271880 650_7 $$2Other$$aMicroglia
000271880 650_7 $$2Other$$aMouse models
000271880 650_7 $$2Other$$aMultiple sclerosis
000271880 650_7 $$2Other$$aTwo-photon microscopy
000271880 650_2 $$2MeSH$$aMicroglia: metabolism
000271880 650_2 $$2MeSH$$aMicroglia: pathology
000271880 650_2 $$2MeSH$$aAnimals
000271880 650_2 $$2MeSH$$aHumans
000271880 650_2 $$2MeSH$$aMicroscopy, Fluorescence, Multiphoton
000271880 650_2 $$2MeSH$$aBrain: diagnostic imaging
000271880 650_2 $$2MeSH$$aNeuroinflammatory Diseases: diagnostic imaging
000271880 650_2 $$2MeSH$$aNeuroinflammatory Diseases: pathology
000271880 650_2 $$2MeSH$$aNeurodegenerative Diseases: diagnostic imaging
000271880 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000271880 7001_ $$0P:(DE-2719)2679991$$aFuhrmann, Martin$$b1$$udzne
000271880 7001_ $$aGaraschuk, Olga$$b2
000271880 7001_ $$aDavalos, Dimitrios$$b3
000271880 773__ $$a10.1007/978-3-031-55529-9_5
000271880 8564_ $$uhttps://pub.dzne.de/record/271880/files/DZNE-2024-01092_Restricted.pdf
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000271880 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2679991$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000271880 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000271880 9141_ $$y2024
000271880 9201_ $$0I:(DE-2719)1011004$$kAG Fuhrmann$$lNeuroimmunology and Imaging$$x0
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