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@INBOOK{Crockett:271880,
      author       = {Crockett, Alexis and Fuhrmann, Martin and Garaschuk, Olga
                      and Davalos, Dimitrios},
      title        = {{P}rogress in {S}tructural and {F}unctional {I}n {V}ivo
                      {I}maging of {M}icroglia and {T}heir {A}pplication in
                      {H}ealth and {D}isease.},
      volume       = {37},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {DZNE-2024-01092},
      isbn         = {978-3-031-55528-2 (print)},
      series       = {Advances in Neurobiology},
      pages        = {65 - 80},
      year         = {2024},
      comment      = {Microglia / Tremblay, Marie-Ève (Editor) ; Cham : Springer
                      International Publishing, 2024, Chapter 5 ; ISSN:
                      2190-5215=2190-5223 ; ISBN:
                      978-3-031-55528-2=978-3-031-55529-9 ;
                      doi:10.1007/978-3-031-55529-9},
      booktitle     = {Microglia / Tremblay, Marie-Ève
                       (Editor) ; Cham : Springer
                       International Publishing, 2024, Chapter
                       5 ; ISSN: 2190-5215=2190-5223 ; ISBN:
                       978-3-031-55528-2=978-3-031-55529-9 ;
                       doi:10.1007/978-3-031-55529-9},
      abstract     = {The first line of defense for the central nervous system
                      (CNS) against injury or disease is provided by microglia.
                      Microglia were long believed to stay in a dormant/resting
                      state, reacting only to injury or disease. This view changed
                      dramatically with the development of modern imaging
                      techniques that allowed the study of microglial behavior in
                      the intact brain over time, to reveal the dynamic nature of
                      their responses. Over the past two decades, in vivo imaging
                      using multiphoton microscopy has revealed numerous new
                      functions of microglia in the developing, adult, aged,
                      injured, and diseased CNS. As the most dynamic cells in the
                      brain, microglia continuously contact all structures and
                      cell types, such as glial and vascular cells, neuronal cell
                      bodies, axons, dendrites, and dendritic spines, and are
                      believed to play a central role in sculpting neuronal
                      networks throughout life. Following trauma, or in
                      neurodegenerative or neuroinflammatory diseases, microglial
                      responses range from protective to harmful, underscoring the
                      need to better understand their diverse roles and states in
                      different pathological conditions. In this chapter, we
                      introduce multiphoton microscopy and discuss recent advances
                      in structural and functional imaging technologies that have
                      expanded our toolbox to study microglial states and
                      behaviors in new ways and depths. We also discuss relevant
                      mouse models available for in vivo imaging studies of
                      microglia and review how such studies are constantly
                      refining our understanding of the multifaceted role of
                      microglia in the healthy and diseased CNS.},
      keywords     = {Microglia: metabolism / Microglia: pathology / Animals /
                      Humans / Microscopy, Fluorescence, Multiphoton / Brain:
                      diagnostic imaging / Neuroinflammatory Diseases: diagnostic
                      imaging / Neuroinflammatory Diseases: pathology /
                      Neurodegenerative Diseases: diagnostic imaging /
                      Neurodegenerative Diseases: pathology / Alzheimer’s
                      disease (Other) / Imaging technologies and methods (Other) /
                      In vitro experiments (Other) / In vivo imaging (Other) /
                      Microglia (Other) / Mouse models (Other) / Multiple
                      sclerosis (Other) / Two-photon microscopy (Other)},
      cin          = {AG Fuhrmann},
      cid          = {I:(DE-2719)1011004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:39207687},
      doi          = {10.1007/978-3-031-55529-9_5},
      url          = {https://pub.dzne.de/record/271880},
}