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@ARTICLE{Arner:271882,
      author       = {Arner, Anja and Ettinger, Andreas and Blaser, Bradley Wayne
                      and Schmid, Bettina and Jeremias, Irmela and Rostam, Nadia
                      and Binder-Blaser, Vera},
      title        = {{I}n vivo monitoring of leukemia-niche interactions in a
                      zebrafish xenograft model.},
      journal      = {PLOS ONE},
      volume       = {19},
      number       = {8},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2024-01094},
      pages        = {e0309415},
      year         = {2024},
      abstract     = {Acute lymphoblastic leukemia (ALL) is the most common type
                      of malignancy in children. ALL prognosis after initial
                      diagnosis is generally good; however, patients suffering
                      from relapse have a poor outcome. The tumor microenvironment
                      is recognized as an important contributor to relapse, yet
                      the cell-cell interactions involved are complex and
                      difficult to study in traditional experimental models. In
                      the present study, we established an innovative larval
                      zebrafish xenotransplantation model, that allows the
                      analysis of leukemic cells (LCs) within an orthotopic niche
                      using time-lapse microscopic and flow cytometric approaches.
                      LCs homed, engrafted and proliferated within the
                      hematopoietic niche at the time of transplant, the caudal
                      hematopoietic tissue (CHT). A specific dissemination pattern
                      of LCs within the CHT was recorded, as they extravasated
                      over time and formed clusters close to the dorsal aorta.
                      Interactions of LCs with macrophages and endothelial cells
                      could be quantitatively characterized. This zebrafish model
                      will allow the quantitative analysis of LCs in a functional
                      and complex microenvironment, to study mechanisms of niche
                      mediated leukemogenesis, leukemia maintenance and relapse
                      development.},
      keywords     = {Animals / Zebrafish / Tumor Microenvironment / Precursor
                      Cell Lymphoblastic Leukemia-Lymphoma: pathology / Humans /
                      Disease Models, Animal / Cell Communication / Heterografts /
                      Stem Cell Niche / Cell Line, Tumor / Endothelial Cells:
                      pathology / Macrophages: pathology / Macrophages: metabolism
                      / Transplantation, Heterologous},
      cin          = {AG Schmid München},
      ddc          = {610},
      cid          = {I:(DE-2719)1140002},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11364250},
      pubmed       = {pmid:39213296},
      doi          = {10.1371/journal.pone.0309415},
      url          = {https://pub.dzne.de/record/271882},
}