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001     271882
005     20250127091554.0
024 7 _ |a pmc:PMC11364250
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037 _ _ |a DZNE-2024-01094
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Arner, Anja
|b 0
245 _ _ |a In vivo monitoring of leukemia-niche interactions in a zebrafish xenograft model.
260 _ _ |a San Francisco, California, US
|c 2024
|b PLOS
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520 _ _ |a Acute lymphoblastic leukemia (ALL) is the most common type of malignancy in children. ALL prognosis after initial diagnosis is generally good; however, patients suffering from relapse have a poor outcome. The tumor microenvironment is recognized as an important contributor to relapse, yet the cell-cell interactions involved are complex and difficult to study in traditional experimental models. In the present study, we established an innovative larval zebrafish xenotransplantation model, that allows the analysis of leukemic cells (LCs) within an orthotopic niche using time-lapse microscopic and flow cytometric approaches. LCs homed, engrafted and proliferated within the hematopoietic niche at the time of transplant, the caudal hematopoietic tissue (CHT). A specific dissemination pattern of LCs within the CHT was recorded, as they extravasated over time and formed clusters close to the dorsal aorta. Interactions of LCs with macrophages and endothelial cells could be quantitatively characterized. This zebrafish model will allow the quantitative analysis of LCs in a functional and complex microenvironment, to study mechanisms of niche mediated leukemogenesis, leukemia maintenance and relapse development.
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Zebrafish
|2 MeSH
650 _ 2 |a Tumor Microenvironment
|2 MeSH
650 _ 2 |a Precursor Cell Lymphoblastic Leukemia-Lymphoma: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Cell Communication
|2 MeSH
650 _ 2 |a Heterografts
|2 MeSH
650 _ 2 |a Stem Cell Niche
|2 MeSH
650 _ 2 |a Cell Line, Tumor
|2 MeSH
650 _ 2 |a Endothelial Cells: pathology
|2 MeSH
650 _ 2 |a Macrophages: pathology
|2 MeSH
650 _ 2 |a Macrophages: metabolism
|2 MeSH
650 _ 2 |a Transplantation, Heterologous
|2 MeSH
700 1 _ |a Ettinger, Andreas
|b 1
700 1 _ |a Blaser, Bradley Wayne
|b 2
700 1 _ |a Schmid, Bettina
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700 1 _ |a Jeremias, Irmela
|b 4
700 1 _ |a Rostam, Nadia
|b 5
700 1 _ |a Binder-Blaser, Vera
|0 0009-0004-1798-8788
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773 _ _ |a 10.1371/journal.pone.0309415
|g Vol. 19, no. 8, p. e0309415 -
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|t PLOS ONE
|v 19
|y 2024
|x 1932-6203
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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