%0 Journal Article
%A Dörner, Marc
%A Tyndall, Anthony
%A Hainc, Nicolin
%A von Känel, Roland
%A Neumann, Katja
%A Euler, Sebastian
%A Schreiber, Frank
%A Ulbrich, Philipp
%A Fuchs, Erelle
%A Garz, Cornelia
%A Glanz, Wenzel
%A Butryn, Michaela
%A Schulze, Jan Ben
%A Schiebler, Sarah Lavinia Florence
%A John, Anna-Charlotte
%A Hildebrand, Annkatrin
%A Hofmann, Andreas B
%A Machetanz, Lena
%A Kirchebner, Johannes
%A Tacik, Pawel
%A Grimm, Alexander
%A Jansen, Robin
%A Pawlitzki, Marc
%A Henneicke, Solveig
%A Bernal, Jose
%A Perosa, Valentina
%A Düzel, Emrah
%A Meuth, Sven G
%A Vielhaber, Stefan
%A Mattern, Hendrik
%A Schreiber, Stefanie
%T Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy - a cross-sectional study.
%J Alzheimer's research & therapy
%V 16
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DZNE-2024-01113
%P 196
%D 2024
%X While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms (NPS) and lifelong mental activities in these patients are scarce. Since NPS are associated with functional impairment, faster cognitive decline and faster progression to death, replication studies in more diverse settings and samples are warranted.We prospectively recruited n = 69 CAA patients and n = 18 cognitively normal controls (NC). The number and severity of NPS were assessed using the Alzheimer's Disease (AD) Assessment Scale's (ADAS) noncognitive subscale. We applied different regression models exploring associations between NPS number or severity and group status (CAA vs. NC), CAA severity assessed with magnetic resonance imaging (MRI) or cognitive function (Mini-Mental State Examination (MMSE), ADAS cognitive subscale), adjusting for age, sex, years of education, arterial hypertension, AD pathology, and apolipoprotein E status. Mediation analyses were performed to test indirect effects of lifelong mental activities on CAA severity and NPS.Patients with CAA had 4.86 times (95
%K Humans
%K Female
%K Male
%K Aged
%K Cross-Sectional Studies
%K Cerebral Amyloid Angiopathy: diagnostic imaging
%K Cerebral Amyloid Angiopathy: psychology
%K Magnetic Resonance Imaging
%K Neuropsychological Tests
%K Middle Aged
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: etiology
%K Prospective Studies
%K Severity of Illness Index
%K Aged, 80 and over
%K Alzheimer’s disease (Other)
%K Cerebral amyloid angiopathy (Other)
%K Depression (Other)
%K Lifelong mental activities (Other)
%K Magnetic resonance imaging (Other)
%K Neuropsychiatric symptoms (Other)
%K White matter hyperintensities (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39232823
%2 pmc:PMC11375846
%R 10.1186/s13195-024-01519-3
%U https://pub.dzne.de/record/271971