TY  - JOUR
AU  - Dörner, Marc
AU  - Tyndall, Anthony
AU  - Hainc, Nicolin
AU  - von Känel, Roland
AU  - Neumann, Katja
AU  - Euler, Sebastian
AU  - Schreiber, Frank
AU  - Ulbrich, Philipp
AU  - Fuchs, Erelle
AU  - Garz, Cornelia
AU  - Glanz, Wenzel
AU  - Butryn, Michaela
AU  - Schulze, Jan Ben
AU  - Schiebler, Sarah Lavinia Florence
AU  - John, Anna-Charlotte
AU  - Hildebrand, Annkatrin
AU  - Hofmann, Andreas B
AU  - Machetanz, Lena
AU  - Kirchebner, Johannes
AU  - Tacik, Pawel
AU  - Grimm, Alexander
AU  - Jansen, Robin
AU  - Pawlitzki, Marc
AU  - Henneicke, Solveig
AU  - Bernal, Jose
AU  - Perosa, Valentina
AU  - Düzel, Emrah
AU  - Meuth, Sven G
AU  - Vielhaber, Stefan
AU  - Mattern, Hendrik
AU  - Schreiber, Stefanie
TI  - Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy - a cross-sectional study.
JO  - Alzheimer's research & therapy
VL  - 16
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2024-01113
SP  - 196
PY  - 2024
AB  - While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms (NPS) and lifelong mental activities in these patients are scarce. Since NPS are associated with functional impairment, faster cognitive decline and faster progression to death, replication studies in more diverse settings and samples are warranted.We prospectively recruited n = 69 CAA patients and n = 18 cognitively normal controls (NC). The number and severity of NPS were assessed using the Alzheimer's Disease (AD) Assessment Scale's (ADAS) noncognitive subscale. We applied different regression models exploring associations between NPS number or severity and group status (CAA vs. NC), CAA severity assessed with magnetic resonance imaging (MRI) or cognitive function (Mini-Mental State Examination (MMSE), ADAS cognitive subscale), adjusting for age, sex, years of education, arterial hypertension, AD pathology, and apolipoprotein E status. Mediation analyses were performed to test indirect effects of lifelong mental activities on CAA severity and NPS.Patients with CAA had 4.86 times (95
KW  - Humans
KW  - Female
KW  - Male
KW  - Aged
KW  - Cross-Sectional Studies
KW  - Cerebral Amyloid Angiopathy: diagnostic imaging
KW  - Cerebral Amyloid Angiopathy: psychology
KW  - Magnetic Resonance Imaging
KW  - Neuropsychological Tests
KW  - Middle Aged
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: etiology
KW  - Prospective Studies
KW  - Severity of Illness Index
KW  - Aged, 80 and over
KW  - Alzheimer’s disease (Other)
KW  - Cerebral amyloid angiopathy (Other)
KW  - Depression (Other)
KW  - Lifelong mental activities (Other)
KW  - Magnetic resonance imaging (Other)
KW  - Neuropsychiatric symptoms (Other)
KW  - White matter hyperintensities (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39232823
C2  - pmc:PMC11375846
DO  - DOI:10.1186/s13195-024-01519-3
UR  - https://pub.dzne.de/record/271971
ER  -