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@ARTICLE{Drner:271971,
      author       = {Dörner, Marc and Tyndall, Anthony and Hainc, Nicolin and
                      von Känel, Roland and Neumann, Katja and Euler, Sebastian
                      and Schreiber, Frank and Ulbrich, Philipp and Fuchs, Erelle
                      and Garz, Cornelia and Glanz, Wenzel and Butryn, Michaela
                      and Schulze, Jan Ben and Schiebler, Sarah Lavinia Florence
                      and John, Anna-Charlotte and Hildebrand, Annkatrin and
                      Hofmann, Andreas B and Machetanz, Lena and Kirchebner,
                      Johannes and Tacik, Pawel and Grimm, Alexander and Jansen,
                      Robin and Pawlitzki, Marc and Henneicke, Solveig and Bernal,
                      Jose and Perosa, Valentina and Düzel, Emrah and Meuth, Sven
                      G and Vielhaber, Stefan and Mattern, Hendrik and Schreiber,
                      Stefanie},
      title        = {{N}europsychiatric symptoms and lifelong mental activities
                      in cerebral amyloid angiopathy - a cross-sectional study.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {16},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2024-01113},
      pages        = {196},
      year         = {2024},
      abstract     = {While several studies in cerebral amyloid angiopathy (CAA)
                      focus on cognitive function, data on neuropsychiatric
                      symptoms (NPS) and lifelong mental activities in these
                      patients are scarce. Since NPS are associated with
                      functional impairment, faster cognitive decline and faster
                      progression to death, replication studies in more diverse
                      settings and samples are warranted.We prospectively
                      recruited n = 69 CAA patients and n = 18 cognitively normal
                      controls (NC). The number and severity of NPS were assessed
                      using the Alzheimer's Disease (AD) Assessment Scale's (ADAS)
                      noncognitive subscale. We applied different regression
                      models exploring associations between NPS number or severity
                      and group status (CAA vs. NC), CAA severity assessed with
                      magnetic resonance imaging (MRI) or cognitive function
                      (Mini-Mental State Examination (MMSE), ADAS cognitive
                      subscale), adjusting for age, sex, years of education,
                      arterial hypertension, AD pathology, and apolipoprotein E
                      status. Mediation analyses were performed to test indirect
                      effects of lifelong mental activities on CAA severity and
                      NPS.Patients with CAA had 4.86 times $(95\%$ CI 2.20-10.73)
                      more NPS and 3.56 units $(95\%$ CI 1.94-5.19) higher
                      expected NPS severity than NC. Higher total CAA severity on
                      MRI predicted 1.14 times $(95\%$ CI 1.01.-1.27) more NPS and
                      0.57 units $(95\%$ CI 0.19-0.95) higher expected NPS
                      severity. More severe white matter hyperintensities were
                      associated with 1.21 times more NPS $(95\%$ CI 1.05-1.39)
                      and 0.63 units $(95\%$ CI 0.19-1.08) more severe NPS. NPS
                      number (MMSE mean difference - 1.15, $95\%$ CI -1.67 to
                      -0.63; ADAS cognitive mean difference 1.91, $95\%$ CI
                      1.26-2.56) and severity (MMSE - 0.55, $95\%$ CI -0.80 to
                      -0.30; ADAS cognitive mean difference 0.89, $95\%$ CI
                      0.57-1.21) predicted lower cognitive function. Greater
                      lifelong mental activities partially mediated the
                      relationship between CAA severity and NPS (indirect effect
                      0.05, $95\%$ CI 0.0007-0.13), and greater lifelong mental
                      activities led to less pronounced CAA severity and thus to
                      less NPS (indirect effect - 0.08, $95\%$ CI -0.22 to
                      -0.002).This study suggests that NPS are common in CAA, and
                      that this relationship may be driven by CAA severity.
                      Furthermore, NPS seem to be tied to lower cognitive
                      function. However, lifelong mental activities might mitigate
                      the impact of NPS in CAA.},
      keywords     = {Humans / Female / Male / Aged / Cross-Sectional Studies /
                      Cerebral Amyloid Angiopathy: diagnostic imaging / Cerebral
                      Amyloid Angiopathy: psychology / Magnetic Resonance Imaging
                      / Neuropsychological Tests / Middle Aged / Cognitive
                      Dysfunction: diagnostic imaging / Cognitive Dysfunction:
                      etiology / Prospective Studies / Severity of Illness Index /
                      Aged, 80 and over / Alzheimer’s disease (Other) / Cerebral
                      amyloid angiopathy (Other) / Depression (Other) / Lifelong
                      mental activities (Other) / Magnetic resonance imaging
                      (Other) / Neuropsychiatric symptoms (Other) / White matter
                      hyperintensities (Other)},
      cin          = {AG Schreiber / AG Düzel / AG Spottke},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010 / I:(DE-2719)5000006 /
                      I:(DE-2719)1011103},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39232823},
      pmc          = {pmc:PMC11375846},
      doi          = {10.1186/s13195-024-01519-3},
      url          = {https://pub.dzne.de/record/271971},
}