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@ARTICLE{Hasegawa:271987,
      author       = {Hasegawa, Masashi and Huang, Ziyan and Paricio-Montesinos,
                      Ricardo and Gründemann, Jan},
      title        = {{N}etwork state changes in sensory thalamus represent
                      learned outcomes.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2024-01121},
      pages        = {7830},
      year         = {2024},
      abstract     = {Thalamic brain areas play an important role in adaptive
                      behaviors. Nevertheless, the population dynamics of thalamic
                      relays during learning across sensory modalities remain
                      unknown. Using a cross-modal sensory reward-associative
                      learning paradigm combined with deep brain two-photon
                      calcium imaging of large populations of auditory thalamus
                      (medial geniculate body, MGB) neurons in male mice, we
                      identified that MGB neurons are biased towards reward
                      predictors independent of modality. Additionally, functional
                      classes of MGB neurons aligned with distinct task periods
                      and behavioral outcomes, both dependent and independent of
                      sensory modality. During non-sensory delay periods, MGB
                      ensembles developed coherent neuronal representation as well
                      as distinct co-activity network states reflecting predicted
                      task outcome. These results demonstrate flexible cross-modal
                      ensemble coding in auditory thalamus during adaptive
                      learning and highlight its importance in brain-wide
                      cross-modal computations during complex behavior.},
      keywords     = {Animals / Male / Mice / Geniculate Bodies: physiology /
                      Thalamus: physiology / Reward / Neurons: physiology /
                      Learning: physiology / Mice, Inbred C57BL},
      cin          = {AG Gründemann},
      ddc          = {500},
      cid          = {I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11380690},
      pubmed       = {pmid:39244616},
      doi          = {10.1038/s41467-024-51868-8},
      url          = {https://pub.dzne.de/record/271987},
}