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001     271987
005     20250127091542.0
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024 7 _ |a 10.1038/s41467-024-51868-8
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037 _ _ |a DZNE-2024-01121
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100 1 _ |a Hasegawa, Masashi
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245 _ _ |a Network state changes in sensory thalamus represent learned outcomes.
260 _ _ |a [London]
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|b Nature Publishing Group UK
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520 _ _ |a Thalamic brain areas play an important role in adaptive behaviors. Nevertheless, the population dynamics of thalamic relays during learning across sensory modalities remain unknown. Using a cross-modal sensory reward-associative learning paradigm combined with deep brain two-photon calcium imaging of large populations of auditory thalamus (medial geniculate body, MGB) neurons in male mice, we identified that MGB neurons are biased towards reward predictors independent of modality. Additionally, functional classes of MGB neurons aligned with distinct task periods and behavioral outcomes, both dependent and independent of sensory modality. During non-sensory delay periods, MGB ensembles developed coherent neuronal representation as well as distinct co-activity network states reflecting predicted task outcome. These results demonstrate flexible cross-modal ensemble coding in auditory thalamus during adaptive learning and highlight its importance in brain-wide cross-modal computations during complex behavior.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Geniculate Bodies: physiology
|2 MeSH
650 _ 2 |a Thalamus: physiology
|2 MeSH
650 _ 2 |a Reward
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Learning: physiology
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
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700 1 _ |a Huang, Ziyan
|0 P:(DE-2719)9001374
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700 1 _ |a Paricio-Montesinos, Ricardo
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700 1 _ |a Gründemann, Jan
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773 _ _ |a 10.1038/s41467-024-51868-8
|g Vol. 15, no. 1, p. 7830
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|t Nature Communications
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|x 2041-1723
787 0 _ |a Hasegawa, Masashi et.al.
|d Cold Spring Harbor : Cold Spring Harbor Laboratory, NY, 2023
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|t Network state changes in sensory thalamus represent learned outcomes
856 4 _ |u https://pub.dzne.de/record/271987/files/DZNE-2024-01121%20SUP%2BSRC.zip
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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