%0 Journal Article
%A Hasoon, Jahfer
%A Hamilton, Calum A
%A Schumacher, Julia
%A Colloby, Sean
%A Donaghy, Paul C
%A Thomas, Alan J
%A Taylor, John-Paul
%T EEG Functional Connectivity Differences Predict Future Conversion to Dementia in Mild Cognitive Impairment With Lewy Body or Alzheimer Disease.
%J International journal of geriatric psychiatry
%V 39
%N 9
%@ 0885-6230
%C Chichester [u.a.]
%I Wiley
%M DZNE-2024-01124
%P e6138
%D 2024
%X Predicting which individuals may convert to dementia from mild cognitive impairment (MCI) remains difficult in clinical practice. Electroencephalography (EEG) is a widely available investigation but there is limited research exploring EEG connectivity differences in patients with MCI who convert to dementia.Participants with a diagnosis of MCI due to Alzheimer's disease (MCI-AD) or Lewy body disease (MCI-LB) underwent resting state EEG recording. They were followed up annually with a review of the clinical diagnosis (n = 66). Participants with a diagnosis of dementia at year 1 or year 2 follow up were classed as converters (n = 23) and those with a diagnosis of MCI at year 2 were classed as stable (n = 43). We used phase lag index (PLI) to estimate functional connectivity as well as analysing dominant frequency (DF) and relative band power. The Network-based statistic (NBS) toolbox was used to assess differences in network topology.The converting group had reduced DF (U = 285.5, p = 0.005) and increased relative pre-alpha power (U = 702, p = 0.005) consistent with previous findings. PLI showed reduced average beta band synchrony in the converting group (U = 311, p = 0.014) as well as significant differences in alpha and beta network topology. Logistic regression models using regional beta PLI values revealed that right central to right lateral (Sens = 56.5
%K Humans
%K Cognitive Dysfunction: physiopathology
%K Cognitive Dysfunction: etiology
%K Lewy Body Disease: physiopathology
%K Female
%K Alzheimer Disease: physiopathology
%K Electroencephalography: methods
%K Male
%K Aged
%K Disease Progression
%K Aged, 80 and over
%K Lewy body disease (Other)
%K cognitive dysfunction (Other)
%K dementia (Other)
%K disease progression (Other)
%K electroencephalography (Other)
%K functional connectivity (Other)
%K prediction (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39261275
%R 10.1002/gps.6138
%U https://pub.dzne.de/record/272081