TY  - JOUR
AU  - Hasoon, Jahfer
AU  - Hamilton, Calum A
AU  - Schumacher, Julia
AU  - Colloby, Sean
AU  - Donaghy, Paul C
AU  - Thomas, Alan J
AU  - Taylor, John-Paul
TI  - EEG Functional Connectivity Differences Predict Future Conversion to Dementia in Mild Cognitive Impairment With Lewy Body or Alzheimer Disease.
JO  - International journal of geriatric psychiatry
VL  - 39
IS  - 9
SN  - 0885-6230
CY  - Chichester [u.a.]
PB  - Wiley
M1  - DZNE-2024-01124
SP  - e6138
PY  - 2024
AB  - Predicting which individuals may convert to dementia from mild cognitive impairment (MCI) remains difficult in clinical practice. Electroencephalography (EEG) is a widely available investigation but there is limited research exploring EEG connectivity differences in patients with MCI who convert to dementia.Participants with a diagnosis of MCI due to Alzheimer's disease (MCI-AD) or Lewy body disease (MCI-LB) underwent resting state EEG recording. They were followed up annually with a review of the clinical diagnosis (n = 66). Participants with a diagnosis of dementia at year 1 or year 2 follow up were classed as converters (n = 23) and those with a diagnosis of MCI at year 2 were classed as stable (n = 43). We used phase lag index (PLI) to estimate functional connectivity as well as analysing dominant frequency (DF) and relative band power. The Network-based statistic (NBS) toolbox was used to assess differences in network topology.The converting group had reduced DF (U = 285.5, p = 0.005) and increased relative pre-alpha power (U = 702, p = 0.005) consistent with previous findings. PLI showed reduced average beta band synchrony in the converting group (U = 311, p = 0.014) as well as significant differences in alpha and beta network topology. Logistic regression models using regional beta PLI values revealed that right central to right lateral (Sens = 56.5
KW  - Humans
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognitive Dysfunction: etiology
KW  - Lewy Body Disease: physiopathology
KW  - Female
KW  - Alzheimer Disease: physiopathology
KW  - Electroencephalography: methods
KW  - Male
KW  - Aged
KW  - Disease Progression
KW  - Aged, 80 and over
KW  - Lewy body disease (Other)
KW  - cognitive dysfunction (Other)
KW  - dementia (Other)
KW  - disease progression (Other)
KW  - electroencephalography (Other)
KW  - functional connectivity (Other)
KW  - prediction (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39261275
DO  - DOI:10.1002/gps.6138
UR  - https://pub.dzne.de/record/272081
ER  -