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| Home > Publications Database > ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. > print |
| Home > Publications Database > ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. > print |
| 001 | 272136 | ||
| 005 | 20250127091553.0 | ||
| 024 | 7 | _ | |a pmc:PMC11480862 |2 pmc |
| 024 | 7 | _ | |a 10.1016/j.xgen.2024.100642 |2 doi |
| 024 | 7 | _ | |a pmid:39216475 |2 pmid |
| 024 | 7 | _ | |a altmetric:166818088 |2 altmetric |
| 037 | _ | _ | |a DZNE-2024-01131 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Tayran, Hüseyin |b 0 |
| 245 | _ | _ | |a ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. |
| 260 | _ | _ | |a Amsterdam |c 2024 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1727089339_25599 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk, yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9-mediated abca7 knockout zebrafish to explore ABCA7's role in AD. Single-cell transcriptomics in heterozygous abca7+/- knockout combined with Aβ42 toxicity revealed that ABCA7 is crucial for neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), and nerve growth factor receptor (NGFR) expressions, which are crucial for synaptic integrity, astroglial proliferation, and microglial prevalence. Impaired NPY induction decreased BDNF and synaptic density, which are rescuable with ectopic NPY. In induced pluripotent stem cell-derived human neurons exposed to Aβ42, ABCA7-/- suppresses NPY. Clinical data showed reduced NPY in AD correlated with elevated Braak stages, genetic variants in NPY associated with AD, and epigenetic changes in NPY, NGFR, and BDNF promoters linked to ABCA7 variants. Therefore, ABCA7-dependent NPY signaling via BDNF-NGFR maintains synaptic integrity, implicating its impairment in increased AD risk through reduced brain resilience. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Brain-Derived Neurotrophic Factor |2 NLM Chemicals |
| 650 | _ | 7 | |a Neuropeptide Y |2 NLM Chemicals |
| 650 | _ | 7 | |a ATP-Binding Cassette Transporters |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Nerve Growth Factor |2 NLM Chemicals |
| 650 | _ | 7 | |a Zebrafish Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 2 | |a Brain-Derived Neurotrophic Factor: metabolism |2 MeSH |
| 650 | _ | 2 | |a Brain-Derived Neurotrophic Factor: genetics |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: metabolism |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: pathology |2 MeSH |
| 650 | _ | 2 | |a Neuropeptide Y: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neuropeptide Y: genetics |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Zebrafish |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction |2 MeSH |
| 650 | _ | 2 | |a Synapses: metabolism |2 MeSH |
| 650 | _ | 2 | |a Synapses: pathology |2 MeSH |
| 650 | _ | 2 | |a ATP-Binding Cassette Transporters: genetics |2 MeSH |
| 650 | _ | 2 | |a ATP-Binding Cassette Transporters: metabolism |2 MeSH |
| 650 | _ | 2 | |a Receptors, Nerve Growth Factor: genetics |2 MeSH |
| 650 | _ | 2 | |a Receptors, Nerve Growth Factor: metabolism |2 MeSH |
| 650 | _ | 2 | |a Zebrafish Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Zebrafish Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neurons: pathology |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: metabolism |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: genetics |2 MeSH |
| 700 | 1 | _ | |a Yilmaz, Elanur |b 1 |
| 700 | 1 | _ | |a Bhattarai, Prabesh |0 P:(DE-2719)2811306 |b 2 |u dzne |
| 700 | 1 | _ | |a Min, Yuhao |b 3 |
| 700 | 1 | _ | |a Wang, Xue |b 4 |
| 700 | 1 | _ | |a Ma, Yiyi |b 5 |
| 700 | 1 | _ | |a Wang, Ni |b 6 |
| 700 | 1 | _ | |a Jeong, Inyoung |b 7 |
| 700 | 1 | _ | |a Nelson, Nastasia |b 8 |
| 700 | 1 | _ | |a Kassara, Nada |b 9 |
| 700 | 1 | _ | |a Cosacak, Mehmet Ilyas |0 P:(DE-2719)2811286 |b 10 |u dzne |
| 700 | 1 | _ | |a Dogru, Ruya Merve |b 11 |
| 700 | 1 | _ | |a Reyes-Dumeyer, Dolly |b 12 |
| 700 | 1 | _ | |a Stenersen, Jakob Mørkved |b 13 |
| 700 | 1 | _ | |a Reddy, Joseph S |b 14 |
| 700 | 1 | _ | |a Qiao, Min |b 15 |
| 700 | 1 | _ | |a Flaherty, Delaney |b 16 |
| 700 | 1 | _ | |a Gunasekaran, Tamil Iniyan |b 17 |
| 700 | 1 | _ | |a Yang, Zikun |b 18 |
| 700 | 1 | _ | |a Jurisch-Yaksi, Nathalie |b 19 |
| 700 | 1 | _ | |a Teich, Andrew F |b 20 |
| 700 | 1 | _ | |a Kanekiyo, Takahisa |b 21 |
| 700 | 1 | _ | |a Tosto, Giuseppe |b 22 |
| 700 | 1 | _ | |a Vardarajan, Badri N |b 23 |
| 700 | 1 | _ | |a İş, Özkan |b 24 |
| 700 | 1 | _ | |a Ertekin-Taner, Nilüfer |b 25 |
| 700 | 1 | _ | |a Mayeux, Richard |b 26 |
| 700 | 1 | _ | |a Kizil, Caghan |b 27 |
| 773 | _ | _ | |a 10.1016/j.xgen.2024.100642 |g Vol. 4, no. 9, p. 100642 - |0 PERI:(DE-600)3110160-4 |n 9 |p 100642 |t Cell genomics |v 4 |y 2024 |x 2666-979X |
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