%0 Journal Article
%A Son, Hye Joo
%A Kim, Jae Seung
%A Bateman, Randall J
%A Kim, Seonok
%A Llibre-Guerra, Jorge J
%A Day, Gregory S
%A Chhatwal, Jasmeer P
%A Berman, Sarah B
%A Schofield, Peter R
%A Jucker, Mathias
%A Levin, Johannes
%A Lee, Jae-Hong
%A Perrin, Richard J
%A Morris, John C
%A Cruchaga, Carlos
%A Hassenstab, Jason
%A Salloway, Stephen P
%A Lee, Jai-Hyuen
%A Daniels, Alisha
%T Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.
%J Neurology
%V 103
%N 7
%@ 0028-3878
%C [Erscheinungsort nicht ermittelbar]
%I Ovid
%M DZNE-2024-01139
%P e209766
%D 2024
%X It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD.We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments. We performed a 2-pronged comprehensive resilience assessment in each cohort. Cohort 1, incorporating the general resilience definition (cognitive maintenance [Clinical Dementia Rating = 0] despite high pathology), included carriers during the periods of significant CSFp-tau181 variability and grouped into resilience/resistance outcome bins according to the dichotomous pathologic and cognitive statuses, subcategorized by the estimated years from expected symptom onset (EYO). Cohort 2, focused on ADAD-specific genetically determined time frame characterizing the onset predictability, included asymptomatic participants with available preclinical lifestyle data and AAO outcomes and grouped into delayed or earlier AAO relative to the parental AAO. Associations of cognitive, CSFp-tau181, and lifestyle/behavioral predictors with binary outcomes were investigated using logistic regression.Of 320 carriers (age 38.19 ± 10.94 years, female 56.25
%K Humans
%K Female
%K Alzheimer Disease: genetics
%K Alzheimer Disease: psychology
%K Alzheimer Disease: epidemiology
%K Male
%K Middle Aged
%K Resilience, Psychological
%K Age of Onset
%K Adult
%K Longitudinal Studies
%K Cohort Studies
%K Prospective Studies
%K tau Proteins: genetics
%K Life Style
%K Life Change Events
%K Aged
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39270149
%2 pmc:PMC11399067
%R 10.1212/WNL.0000000000209766
%U https://pub.dzne.de/record/272148