TY  - JOUR
AU  - Son, Hye Joo
AU  - Kim, Jae Seung
AU  - Bateman, Randall J
AU  - Kim, Seonok
AU  - Llibre-Guerra, Jorge J
AU  - Day, Gregory S
AU  - Chhatwal, Jasmeer P
AU  - Berman, Sarah B
AU  - Schofield, Peter R
AU  - Jucker, Mathias
AU  - Levin, Johannes
AU  - Lee, Jae-Hong
AU  - Perrin, Richard J
AU  - Morris, John C
AU  - Cruchaga, Carlos
AU  - Hassenstab, Jason
AU  - Salloway, Stephen P
AU  - Lee, Jai-Hyuen
AU  - Daniels, Alisha
TI  - Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.
JO  - Neurology
VL  - 103
IS  - 7
SN  - 0028-3878
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DZNE-2024-01139
SP  - e209766
PY  - 2024
AB  - It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD.We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments. We performed a 2-pronged comprehensive resilience assessment in each cohort. Cohort 1, incorporating the general resilience definition (cognitive maintenance [Clinical Dementia Rating = 0] despite high pathology), included carriers during the periods of significant CSFp-tau181 variability and grouped into resilience/resistance outcome bins according to the dichotomous pathologic and cognitive statuses, subcategorized by the estimated years from expected symptom onset (EYO). Cohort 2, focused on ADAD-specific genetically determined time frame characterizing the onset predictability, included asymptomatic participants with available preclinical lifestyle data and AAO outcomes and grouped into delayed or earlier AAO relative to the parental AAO. Associations of cognitive, CSFp-tau181, and lifestyle/behavioral predictors with binary outcomes were investigated using logistic regression.Of 320 carriers (age 38.19 ± 10.94 years, female 56.25
KW  - Humans
KW  - Female
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: psychology
KW  - Alzheimer Disease: epidemiology
KW  - Male
KW  - Middle Aged
KW  - Resilience, Psychological
KW  - Age of Onset
KW  - Adult
KW  - Longitudinal Studies
KW  - Cohort Studies
KW  - Prospective Studies
KW  - tau Proteins: genetics
KW  - Life Style
KW  - Life Change Events
KW  - Aged
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39270149
C2  - pmc:PMC11399067
DO  - DOI:10.1212/WNL.0000000000209766
UR  - https://pub.dzne.de/record/272148
ER  -