000272338 001__ 272338
000272338 005__ 20240924164122.0
000272338 020__ $$a978-1-0716-4010-4 (print)
000272338 020__ $$a978-1-0716-4011-1 (electronic)
000272338 0247_ $$2doi$$a10.1007/978-1-0716-4011-1_2
000272338 0247_ $$2ISSN$$a0893-2336
000272338 0247_ $$2ISSN$$a1940-6045
000272338 037__ $$aDZNE-2024-01157
000272338 082__ $$a610
000272338 1001_ $$aRusakov, Dmitri$$b0$$eEditor
000272338 245__ $$aQuantitative Optical Analysis of Astrocytic Ca2+ Signaling
000272338 260__ $$aNew York, NY$$bSpringer US$$c2024
000272338 29510 $$aFluorescence Imaging of the Brain / Rusakov, Dmitri (Editor) ; New York, NY : Springer US, 2024, Chapter 2 ; ISSN: 0893-2336=1940-6045 ; ISBN: 978-1-0716-4010-4=978-1-0716-4011-1 ; doi:10.1007/978-1-0716-4011-1
000272338 300__ $$a21 - 57
000272338 3367_ $$2ORCID$$aBOOK_CHAPTER
000272338 3367_ $$07$$2EndNote$$aBook Section
000272338 3367_ $$2DRIVER$$abookPart
000272338 3367_ $$2BibTeX$$aINBOOK
000272338 3367_ $$2DataCite$$aOutput Types/Book chapter
000272338 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1727171183_3424
000272338 4900_ $$aNeuromethods$$v209
000272338 520__ $$aCa2+ signaling of astrocytes plays a central role in the physiology and pathophysiology of these non-neuronal cells in the brain. Decades of research have revealed the heterogeneity of astrocytic Ca2+ signals and how they are triggered, how they propagate, what mechanisms sustain them, and what their downstream effects are on the cellular, network, and behavioral level. Imaging of astrocytic Ca2+ signals has been and is at the center of this research. It has benefited from the development of novel indicators, of new imaging techniques, and of new analytical approaches. This enabled researchers to uncover a striking diversity of Ca2+ signals regarding, for instance, their spatial and temporal patterns, which have been linked to the operation of brain circuits. When interpreting recorded Ca2+ signals it needs to be considered how cellular changes of [Ca2+] are reflected by the recorded fluorescence of a Ca2+ indicator, what available and useful analytical approaches are, and what their advantages and limitations are. Here, we provide an overview of quantitative Ca2+ imaging in astrocytes by covering theoretical and practical aspects of Ca2+ imaging, available indicators and strategies, and toolboxes for image data analysis.
000272338 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000272338 588__ $$aDataset connected to CrossRef Book Series, Journals: pub.dzne.de
000272338 7001_ $$aZeug, André$$b1
000272338 7001_ $$aUnichenko, Petr$$b2
000272338 7001_ $$aMüller, Franziska E.$$b3
000272338 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b4$$eLast author$$udzne
000272338 773__ $$a10.1007/978-1-0716-4011-1_2
000272338 8564_ $$uhttps://pub.dzne.de/record/272338/files/DZNE-2024-01157_Restricted.pdf
000272338 8564_ $$uhttps://pub.dzne.de/record/272338/files/DZNE-2024-01157_Restricted.pdf?subformat=pdfa$$xpdfa
000272338 909CO $$ooai:pub.dzne.de:272338$$pVDB
000272338 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811625$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000272338 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000272338 9141_ $$y2024
000272338 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-19
000272338 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-19
000272338 9201_ $$0I:(DE-2719)1013029$$kAG Henneberger$$lSynaptic and Glial Plasticity$$x0
000272338 980__ $$acontb
000272338 980__ $$aVDB
000272338 980__ $$aI:(DE-2719)1013029
000272338 980__ $$aUNRESTRICTED