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@PHDTHESIS{Dalgge:272347,
      author       = {Dalügge, Dennis},
      title        = {{S}ources of spatial tuning in the dorsal subiculum},
      school       = {Rheinische Friedrich-Wilhelms-Universität Bonn},
      type         = {Dissertation},
      reportid     = {DZNE-2024-01164},
      pages        = {120 pp.},
      year         = {2024},
      note         = {Dissertation, Rheinische Friedrich-Wilhelms-Universität
                      Bonn, 2024},
      abstract     = {Spatial navigation is an essential behavior for all moving
                      life-forms. A main mammalian brain structure implicated in
                      this process is the hippocampal formation. Neuronal firing
                      patterns in this brain region are remarkably correlated to
                      various aspects of the animal’s location and navigation.
                      The subiculum is a primary output structure of hippocampal
                      information processing, providing output to various cortical
                      and subcortical areas. With this crucial position within the
                      hippocampal formation, the primary role of the subiculum is
                      to integrate, compress and then distribute
                      hippocampally-processed information to the whole brain. Two
                      major inputs to the subiculum arise from the CA1 region and
                      the entorhinal cortex. This study investigates the
                      individual roles of these two input streams in generating
                      spatially correlated firing of subicular neurons.In vivo
                      whole cell patch clamp recordings in mice running freely on
                      a circular track revealed that dorsal subicular neurons
                      receive spatially tuned input. Additionally, channelrodopsin
                      assisted circuit mapping showed, that the two major input
                      streams target specific regions in the dendritic tree of
                      dorsal subicular neurons. Specifically, CA1 input is located
                      more proximal, while EC input forms synapses in the distal
                      part of the dendritic tree of dorsal subicular neurons.
                      Finally, individual contributions of both input streams on
                      the spatial tuning of dorsal subicular neurons were
                      investigated using two-photon calcium imaging in mice
                      running on a linear treadmill. Chemogenetic inactivation of
                      either CA1 or entorhinal cortex inputs via viral
                      transduction of the inhibitory DREADD and local application
                      of CNO by a small hole in the imaging window, revealed
                      district contributions of both inputs paths: CA1 inputs are
                      necessary for the place and velocity tuning, while EC inputs
                      are only necessary for the place tuning of dorsal subicular
                      neurons.Taken together my experiments demonstrate that (I)
                      subicular neurons receive spatial and velocity tuned input
                      (II), that subicular neurons maintain a functional input
                      segregation between CA1 and entorhinal cortex synapses and
                      (III) that both input streams play differential roles in
                      shaping the spatial tunings of subicular neurons with
                      respect to place and movement speed. This study emphasizes
                      the need to differentiate between the information that one
                      brain region could potentially receive from other brain
                      regions and the information that is actually used by the
                      postsynaptic neuron during their input-output
                      transformation.},
      cin          = {AG Fuhrmann / LIS / AG Remy},
      cid          = {I:(DE-2719)1011004 / I:(DE-2719)1040260 /
                      I:(DE-2719)1013006},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:5-78590},
      url          = {https://pub.dzne.de/record/272347},
}