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000272349 1001_ $$0P:(DE-2719)9001576$$aMonzel, Merlin$$b0$$eFirst author
000272349 245__ $$aHippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia
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000272349 520__ $$aAphantasia refers to reduced or absent visual imagery. While most of us can readily recall decade-old personal experiences (autobiographical memories, AM) with vivid mental images, there is a dearth of information about whether the loss of visual imagery in aphantasics affects their AM retrieval. The hippocampus is thought to be a crucial hub in a brain-wide network underlying AM. One important question is whether this network, especially the connectivity of the hippocampus, is altered in aphantasia. In the current study, we tested 14 congenital aphantasics and 16 demographically matched controls in an AM fMRI task to investigate how key brain regions (i.e. hippocampus and visual-perceptual cortices) interact with each other during AM re-experiencing. All participants were interviewed regarding their autobiographical memory to examine their episodic and semantic recall of specific events. Aphantasics reported more difficulties in recalling AM, were less confident about their memories, and described less internal and emotional details than controls. Neurally, aphantasics displayed decreased hippocampal and increased visual-perceptual cortex activation during AM retrieval compared to controls. In addition, controls showed strong negative functional connectivity between the hippocampus and the visual cortex during AM and resting-state functional connectivity between these two brain structures predicted better visualization skills. Our results indicate that visual mental imagery plays an important role in detail-rich vivid AM, and that this type of cognitive function is supported by the functional connection between the hippocampus and the visual-perceptual cortex.
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000272349 650_7 $$2Other$$aaphantasia
000272349 650_7 $$2Other$$aautobiographical retrieval
000272349 650_7 $$2Other$$aepisodic memory
000272349 650_7 $$2Other$$afunctional connectivity
000272349 650_7 $$2Other$$ahuman
000272349 650_7 $$2Other$$aneural networks
000272349 650_7 $$2Other$$aneuroscience
000272349 650_7 $$2Other$$avisual cortex
000272349 650_2 $$2MeSH$$aHumans
000272349 650_2 $$2MeSH$$aHippocampus: physiopathology
000272349 650_2 $$2MeSH$$aMale
000272349 650_2 $$2MeSH$$aFemale
000272349 650_2 $$2MeSH$$aMemory, Episodic
000272349 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000272349 650_2 $$2MeSH$$aAdult
000272349 650_2 $$2MeSH$$aMiddle Aged
000272349 650_2 $$2MeSH$$aMental Recall: physiology
000272349 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000272349 650_2 $$2MeSH$$aOccipital Lobe: physiopathology
000272349 650_2 $$2MeSH$$aOccipital Lobe: diagnostic imaging
000272349 650_2 $$2MeSH$$aYoung Adult
000272349 7001_ $$0P:(DE-2719)2812276$$aLeelaarporn, Pitshaporn$$b1$$eFirst author
000272349 7001_ $$0P:(DE-2719)9002173$$aLutz, Teresa$$b2
000272349 7001_ $$0P:(DE-HGF)0$$aSchultz, Johannes$$b3
000272349 7001_ $$0P:(DE-2719)2812752$$aBrunheim, Sascha$$b4
000272349 7001_ $$0P:(DE-2719)2812134$$aReuter, Martin$$b5
000272349 7001_ $$0P:(DE-2719)9000865$$aMcCormick, Cornelia$$b6$$eLast author
000272349 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.94916$$gVol. 13, p. RP94916$$pRP94916$$teLife$$v13$$x2050-084X$$y2024
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