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000272504 1001_ $$0P:(DE-2719)9000538$$aEhrhardt, Maren$$b0$$eFirst author$$udzne
000272504 245__ $$aCircadian rhythm of brain-derived neurotrophic factor in serum and plasma.
000272504 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2024
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000272504 520__ $$aThe neurotrophic growth factor brain-derived neurotrophic factor (BDNF) plays a crucial role in various neurodegenerative and psychiatric diseases, such as Alzheimer's disease, schizophrenia and depression. BDNF has been proposed as a potential biomarker for diagnosis, prognosis and monitoring therapy. Understanding the factors influencing BDNF levels and whether they follow a circadian rhythm is essential for interpreting fluctuations in BDNF measurements. We aimed to investigate the circadian rhythm of BDNF by collecting multiple peripheral venous blood samples from young, healthy male participants at 12 different time points over 24 h. In addition, vital parameters, cortisol and insulin like growth factor 1 (IGF1) were measured to explore potential regulatory mechanisms, interfering variables and their correlations with BDNF concentration. The findings revealed that plasma BDNF did not exhibit any significant fluctuations over 24 h, suggesting the absence of a circadian rhythm. However, serum BDNF levels decreased during sleep. Furthermore, serum BDNF showed a positive correlation with heart rate but a negative correlation with IGF1. No significant correlation was observed between cortisol and BDNF or IGF1. Although plasma BDNF suggests steady-state conditions, the decline of serum BDNF during the nocturnal period could be attributed to physical inactivity and associated with reduced haemodynamic blood flow (heart rate reduction during sleep). The type of sample collection (peripheral venous cannula vs. blood sampling using a butterfly system) does not significantly affect the measured BDNF levels. The sample collection during the day did not significantly affect BDNF analysis, emphasizing the importance of considering activity levels rather than timing when designing standardized protocols for BDNF assessments.
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000272504 650_7 $$2Other$$abiomarker
000272504 650_7 $$2Other$$abrain‐derived neurotrophic factor
000272504 650_7 $$2Other$$acircadian rhythm
000272504 650_7 $$2Other$$asleep
000272504 650_7 $$2NLM Chemicals$$aBrain-Derived Neurotrophic Factor
000272504 650_7 $$0WI4X0X7BPJ$$2NLM Chemicals$$aHydrocortisone
000272504 650_7 $$067763-96-6$$2NLM Chemicals$$aInsulin-Like Growth Factor I
000272504 650_7 $$07171WSG8A2$$2NLM Chemicals$$aBDNF protein, human
000272504 650_7 $$2NLM Chemicals$$aIGF1 protein, human
000272504 650_2 $$2MeSH$$aHumans
000272504 650_2 $$2MeSH$$aMale
000272504 650_2 $$2MeSH$$aBrain-Derived Neurotrophic Factor: blood
000272504 650_2 $$2MeSH$$aCircadian Rhythm: physiology
000272504 650_2 $$2MeSH$$aHydrocortisone: blood
000272504 650_2 $$2MeSH$$aInsulin-Like Growth Factor I: metabolism
000272504 650_2 $$2MeSH$$aAdult
000272504 650_2 $$2MeSH$$aYoung Adult
000272504 650_2 $$2MeSH$$aHeart Rate: physiology
000272504 650_2 $$2MeSH$$aSleep: physiology
000272504 7001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefanie$$b1$$udzne
000272504 7001_ $$0P:(DE-2719)2812221$$aDuderstadt, Yves$$b2$$udzne
000272504 7001_ $$aBraun-Dullaeus, Rüdiger$$b3
000272504 7001_ $$aBorucki, Katrin$$b4
000272504 7001_ $$aBrigadski, Tanja$$b5
000272504 7001_ $$0P:(DE-2719)2191623$$aMüller, Notger G$$b6$$udzne
000272504 7001_ $$aLeßmann, Volkmar$$b7
000272504 7001_ $$0P:(DE-2719)2811487$$aMüller, Patrick$$b8$$eLast author$$udzne
000272504 773__ $$0PERI:(DE-600)1493802-9$$a10.1113/EP091671$$gVol. 109, no. 10, p. 1755 - 1767$$n10$$p1755 - 1767$$tExperimental physiology$$v109$$x0033-5541$$y2024
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