TY  - JOUR
AU  - Ehrhardt, Maren
AU  - Schreiber, Stefanie
AU  - Duderstadt, Yves
AU  - Braun-Dullaeus, Rüdiger
AU  - Borucki, Katrin
AU  - Brigadski, Tanja
AU  - Müller, Notger G
AU  - Leßmann, Volkmar
AU  - Müller, Patrick
TI  - Circadian rhythm of brain-derived neurotrophic factor in serum and plasma.
JO  - Experimental physiology
VL  - 109
IS  - 10
SN  - 0033-5541
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2024-01180
SP  - 1755 - 1767
PY  - 2024
AB  - The neurotrophic growth factor brain-derived neurotrophic factor (BDNF) plays a crucial role in various neurodegenerative and psychiatric diseases, such as Alzheimer's disease, schizophrenia and depression. BDNF has been proposed as a potential biomarker for diagnosis, prognosis and monitoring therapy. Understanding the factors influencing BDNF levels and whether they follow a circadian rhythm is essential for interpreting fluctuations in BDNF measurements. We aimed to investigate the circadian rhythm of BDNF by collecting multiple peripheral venous blood samples from young, healthy male participants at 12 different time points over 24 h. In addition, vital parameters, cortisol and insulin like growth factor 1 (IGF1) were measured to explore potential regulatory mechanisms, interfering variables and their correlations with BDNF concentration. The findings revealed that plasma BDNF did not exhibit any significant fluctuations over 24 h, suggesting the absence of a circadian rhythm. However, serum BDNF levels decreased during sleep. Furthermore, serum BDNF showed a positive correlation with heart rate but a negative correlation with IGF1. No significant correlation was observed between cortisol and BDNF or IGF1. Although plasma BDNF suggests steady-state conditions, the decline of serum BDNF during the nocturnal period could be attributed to physical inactivity and associated with reduced haemodynamic blood flow (heart rate reduction during sleep). The type of sample collection (peripheral venous cannula vs. blood sampling using a butterfly system) does not significantly affect the measured BDNF levels. The sample collection during the day did not significantly affect BDNF analysis, emphasizing the importance of considering activity levels rather than timing when designing standardized protocols for BDNF assessments.
KW  - Humans
KW  - Male
KW  - Brain-Derived Neurotrophic Factor: blood
KW  - Circadian Rhythm: physiology
KW  - Hydrocortisone: blood
KW  - Insulin-Like Growth Factor I: metabolism
KW  - Adult
KW  - Young Adult
KW  - Heart Rate: physiology
KW  - Sleep: physiology
KW  - biomarker (Other)
KW  - brain‐derived neurotrophic factor (Other)
KW  - circadian rhythm (Other)
KW  - sleep (Other)
KW  - Brain-Derived Neurotrophic Factor (NLM Chemicals)
KW  - Hydrocortisone (NLM Chemicals)
KW  - Insulin-Like Growth Factor I (NLM Chemicals)
KW  - BDNF protein, human (NLM Chemicals)
KW  - IGF1 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11442779
C6  - pmid:39105714
DO  - DOI:10.1113/EP091671
UR  - https://pub.dzne.de/record/272504
ER  -