TY  - JOUR
AU  - Ye, Lan
AU  - Sani, Sam Sadeghi
AU  - Veith Sanches, Linda
AU  - Krey, Lea Farina Magdalena
AU  - Wegner, Florian
AU  - Höllerhage, Matthias
AU  - Schrader, Christoph
AU  - Höglinger, Günter
AU  - Klietz, Martin
TI  - Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses
JO  - Brain Sciences
VL  - 14
IS  - 10
SN  - 2076-3425
CY  - Basel
PB  - MDPI AG
M1  - DZNE-2024-01184
SP  - 991
PY  - 2024
AB  -  The acute levodopa challenge is widely used to distinguish Parkinson's disease (PD) from atypical parkinsonian syndromes (APSs) such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). In APSs, very few patients present a clinically relevant response to levodopa. The aim of this study was to determine whether patients with atypical parkinsonism benefit from levodopa in any aspect of their multiple motor deficits despite the generally poor response. This retrospective study analyzed individual motor responses to the acute levodopa challenge using the MDS-UPDRS III in 47 PSP, 26 MSA, and 71 PD patients at Hannover Medical School. Despite the generally poor levodopa response in both PSP and MSA patients, bradykinesia and rigidity were the symptoms most notably affected by levodopa in PSP patients, while MSA patients experienced significant improvements in bradykinesia and action tremor. These findings underscore the variability in levodopa response among PSP and MSA patients and highlight the need for personalized treatment approaches in atypical parkinsonism.
LB  - PUB:(DE-HGF)16
C6  - pmid:39452005
C2  - pmc:PMC11506334
DO  - DOI:10.3390/brainsci14100991
UR  - https://pub.dzne.de/record/272508
ER  -