% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ye:272508,
      author       = {Ye, Lan and Sani, Sam Sadeghi and Veith Sanches, Linda and
                      Krey, Lea Farina Magdalena and Wegner, Florian and
                      Höllerhage, Matthias and Schrader, Christoph and
                      Höglinger, Günter and Klietz, Martin},
      title        = {{A}cute {L}evodopa {C}hallenge in {A}typical
                      {P}arkinsonism: {C}omprehensive {A}nalysis of {I}ndividual
                      {M}otor {R}esponses},
      journal      = {Brain Sciences},
      volume       = {14},
      number       = {10},
      issn         = {2076-3425},
      address      = {Basel},
      publisher    = {MDPI AG},
      reportid     = {DZNE-2024-01184},
      pages        = {991},
      year         = {2024},
      abstract     = {The acute levodopa challenge is widely used to distinguish
                      Parkinson's disease (PD) from atypical parkinsonian
                      syndromes (APSs) such as multiple system atrophy (MSA) and
                      progressive supranuclear palsy (PSP). In APSs, very few
                      patients present a clinically relevant response to levodopa.
                      The aim of this study was to determine whether patients with
                      atypical parkinsonism benefit from levodopa in any aspect of
                      their multiple motor deficits despite the generally poor
                      response. This retrospective study analyzed individual motor
                      responses to the acute levodopa challenge using the
                      MDS-UPDRS III in 47 PSP, 26 MSA, and 71 PD patients at
                      Hannover Medical School. Despite the generally poor levodopa
                      response in both PSP and MSA patients, bradykinesia and
                      rigidity were the symptoms most notably affected by levodopa
                      in PSP patients, while MSA patients experienced significant
                      improvements in bradykinesia and action tremor. These
                      findings underscore the variability in levodopa response
                      among PSP and MSA patients and highlight the need for
                      personalized treatment approaches in atypical parkinsonism.},
      cin          = {AG Höglinger / Clinical Research (Munich)},
      ddc          = {570},
      cid          = {I:(DE-2719)1110002 / I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39452005},
      pmc          = {pmc:PMC11506334},
      doi          = {10.3390/brainsci14100991},
      url          = {https://pub.dzne.de/record/272508},
}