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@ARTICLE{Bartos:272510,
      author       = {Bartos, Laura M. and Kunte, Sebastian T. and Wagner,
                      Stephan and Beumers, Philipp and Schaefer, Rebecca and
                      Zatcepin, Artem and Li, Yunlei and Griessl, Maria and
                      Hoermann, Leonie and Wind-Mark, Karin and Bartenstein, Peter
                      and Tahirovic, Sabina and Ziegler, Sibylle and Brendel,
                      Matthias and Gnörich, Johannes},
      title        = {{A}stroglial glucose uptake determines brain {FDG}-{PET}
                      alterations and metabolic connectivity during healthy aging
                      in mice},
      journal      = {NeuroImage},
      volume       = {300},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2024-01186},
      pages        = {120860},
      year         = {2024},
      abstract     = {2-Fluorodeoxyglucose-PET (FDG-PET) is a powerful tool to
                      study glucose metabolism in mammalian brains, but cellular
                      sources of glucose uptake and metabolic connectivity during
                      aging are not yet understood.Healthy wild-type mice of both
                      sexes (2-21 months of age) received FDG-PET and cell sorting
                      after in vivo tracer injection (scRadiotracing). FDG uptake
                      per cell was quantified in isolated microglia, astrocytes
                      and neurons. Cerebral FDG uptake and metabolic connectivity
                      were determined by PET. A subset of mice received
                      measurement of blood glucose levels to study associations
                      with cellular FDG uptake during aging.Cerebral FDG-PET
                      signals in healthy mice increased linearly with age.
                      Cellular FDG uptake of neurons increased between 2 and 12
                      months of age, followed by a strong decrease towards late
                      ages. Contrarily, FDG uptake in microglia and astrocytes
                      exhibited a U-shaped function with respect to age,
                      comprising the predominant cellular source of higher
                      cerebral FDG uptake in the later stages. Metabolic
                      connectivity was closely associated with the ratio of
                      glucose uptake in astroglial cells relative to neurons.
                      Cellular FDG uptake was not associated with blood glucose
                      levels and increasing FDG brain uptake as a function of age
                      was still observed after adjusting for blood glucose
                      levels.Trajectories of astroglial glucose uptake drive brain
                      FDG-PET alterations and metabolic connectivity during
                      aging.},
      keywords     = {Animals / Fluorodeoxyglucose F18: pharmacokinetics /
                      Astrocytes: metabolism / Positron-Emission Tomography:
                      methods / Mice / Glucose: metabolism / Male / Brain:
                      metabolism / Brain: diagnostic imaging / Female / Mice,
                      Inbred C57BL / Aging: metabolism / Radiopharmaceuticals:
                      pharmacokinetics / Neurons: metabolism / Healthy Aging:
                      metabolism / Microglia: metabolism / Aging (Other) /
                      Astroglia (Other) / FDG-PET (Other) / Metabolic connectivity
                      (Other) / Scradiotracing (Other) / Fluorodeoxyglucose F18
                      (NLM Chemicals) / Glucose (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals)},
      cin          = {AG Haass / AG Tahirovic},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1140003},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39332748},
      doi          = {10.1016/j.neuroimage.2024.120860},
      url          = {https://pub.dzne.de/record/272510},
}