000272572 001__ 272572
000272572 005__ 20250523100557.0
000272572 0247_ $$2pmc$$apmc:PMC11485070
000272572 0247_ $$2doi$$a10.1002/alz.14197
000272572 0247_ $$2pmid$$apmid:39210637
000272572 0247_ $$2ISSN$$a1552-5260
000272572 0247_ $$2ISSN$$a1552-5279
000272572 037__ $$aDZNE-2024-01193
000272572 041__ $$aEnglish
000272572 082__ $$a610
000272572 1001_ $$0P:(DE-2719)9001389$$aMelas, Konstantinos$$b0$$eFirst author
000272572 245__ $$aBlood-derived microRNAs are related to cognitive domains in the general population.
000272572 260__ $$aHoboken, NJ$$bWiley$$c2024
000272572 3367_ $$2DRIVER$$aarticle
000272572 3367_ $$2DataCite$$aOutput Types/Journal article
000272572 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1747924048_19988
000272572 3367_ $$2BibTeX$$aARTICLE
000272572 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000272572 3367_ $$00$$2EndNote$$aJournal Article
000272572 520__ $$aBlood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel miRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.We examined blood-derived miRNAs and miRNA co-expression clusters in relation to cognitive domains, structural magnetic resonance imaging measures, target gene expression, and genetic variants in 2869 participants of a population-based cohort.Five previously identified and 14 novel miRNAs were associated with cognitive domains. Eleven of these were also associated with cortical thickness and two with hippocampal volume. Multi-omics analysis showed that certain identified miRNAs were genetically influenced and regulated genes in pathways like neurogenesis and synapse assembly.We identified miRNAs associated with cognitive domains, brain regions, and neuronal processes affected by aging and neurodegeneration, making them promising candidate blood-based biomarkers or therapeutic targets of subclinical cognitive dysfunction.We investigated the association of blood-derived microRNAs with cognitive domains. Five previously identified and 14 novel microRNAs were associated with cognition. Eleven cognition-related microRNAs were also associated with cortical thickness. Identified microRNAs were linked to genes associated with neuronal functions. Results provide putative biomarkers or therapeutic targets of cognitive aging.
000272572 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000272572 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1
000272572 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x2
000272572 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000272572 650_7 $$2Other$$abiomarker
000272572 650_7 $$2Other$$acognition
000272572 650_7 $$2Other$$acortical thickness
000272572 650_7 $$2Other$$amiR‐10401‐3p
000272572 650_7 $$2Other$$amiR‐125b‐5p
000272572 650_7 $$2Other$$amiR‐128‐3p
000272572 650_7 $$2Other$$amiR‐134‐5p
000272572 650_7 $$2Other$$amiR‐192‐5p
000272572 650_7 $$2Other$$amiR‐215‐5p
000272572 650_7 $$2Other$$amiR‐4677‐5p
000272572 650_7 $$2Other$$amiR‐4732‐3p
000272572 650_7 $$2Other$$amiR‐92a‐3p
000272572 650_7 $$2Other$$amiR‐92b‐3p
000272572 650_7 $$2Other$$amicroRNA
000272572 650_7 $$2Other$$apopulation‐based
000272572 650_2 $$2MeSH$$aHumans
000272572 650_2 $$2MeSH$$aMicroRNAs: genetics
000272572 650_2 $$2MeSH$$aMale
000272572 650_2 $$2MeSH$$aFemale
000272572 650_2 $$2MeSH$$aAged
000272572 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000272572 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000272572 650_2 $$2MeSH$$aCognition: physiology
000272572 650_2 $$2MeSH$$aBrain
000272572 650_2 $$2MeSH$$aCohort Studies
000272572 650_2 $$2MeSH$$aMiddle Aged
000272572 650_2 $$2MeSH$$aBiomarkers: blood
000272572 650_2 $$2MeSH$$aHippocampus: pathology
000272572 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000272572 7001_ $$0P:(DE-2719)9001002$$aTalevi, Valentina$$b1
000272572 7001_ $$0P:(DE-2719)9002347$$aImtiaz, Mohammed Aslam$$b2
000272572 7001_ $$0P:(DE-2719)9002576$$aEtteldorf, Rika$$b3
000272572 7001_ $$0P:(DE-2719)2812449$$aEstrada, Santiago$$b4
000272572 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis Manfred$$b5
000272572 7001_ $$0P:(DE-2719)2811063$$aPena-Centeno, Tonatiuh$$b6
000272572 7001_ $$0P:(DE-2719)2812578$$aAziz, N Ahmad$$b7
000272572 7001_ $$0P:(DE-2719)2000047$$aFischer, André$$b8
000272572 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b9$$eLast author
000272572 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14197$$gp. alz.14197$$n10$$p7138 - 7159$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
000272572 7870_ $$0DZNE-2024-00669$$aMelas, Konstantinos et.al.$$d2024$$iRelatedTo$$r$$tCirculating microRNAs are related to cognitive domains in the general population
000272572 8564_ $$uhttps://pub.dzne.de/record/272572/files/DZNE-2024-01193.pdf$$yOpenAccess
000272572 8564_ $$uhttps://pub.dzne.de/record/272572/files/DZNE-2024-01193.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000272572 909CO $$ooai:pub.dzne.de:272572$$pVDB$$popen_access$$pdnbdelivery$$pdriver$$popenaire
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001389$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001002$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002347$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002576$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812449$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812548$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811063$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812578$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000047$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000272572 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810403$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000272572 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000272572 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x1
000272572 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x2
000272572 9141_ $$y2024
000272572 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-25
000272572 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000272572 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bALZHEIMERS DEMENT : 2022$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-10-25$$wger
000272572 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bALZHEIMERS DEMENT : 2022$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000272572 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-25
000272572 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-25
000272572 9201_ $$0I:(DE-2719)1012001$$kAG Breteler$$lPopulation Health Sciences$$x0
000272572 9201_ $$0I:(DE-2719)5000071$$kAG Aziz$$lPopulation & Clinical Neuroepidemiology$$x1
000272572 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x2
000272572 9201_ $$0I:(DE-2719)1440016$$kBioinformatics Unit (Göttingen)$$lBioinformatics and Genome Dynamics Core (Göttingen)$$x3
000272572 980__ $$ajournal
000272572 980__ $$aVDB
000272572 980__ $$aI:(DE-2719)1012001
000272572 980__ $$aI:(DE-2719)5000071
000272572 980__ $$aI:(DE-2719)1410002
000272572 980__ $$aI:(DE-2719)1440016
000272572 980__ $$aUNRESTRICTED
000272572 9801_ $$aFullTexts