TY  - JOUR
AU  - Melas, Konstantinos
AU  - Talevi, Valentina
AU  - Imtiaz, Mohammed Aslam
AU  - Etteldorf, Rika
AU  - Estrada, Santiago
AU  - Krüger, Dennis Manfred
AU  - Pena-Centeno, Tonatiuh
AU  - Aziz, N Ahmad
AU  - Fischer, André
AU  - Breteler, Monique M B
TI  - Blood-derived microRNAs are related to cognitive domains in the general population.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 10
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-01193
SP  - 7138 - 7159
PY  - 2024
AB  - Blood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel miRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.We examined blood-derived miRNAs and miRNA co-expression clusters in relation to cognitive domains, structural magnetic resonance imaging measures, target gene expression, and genetic variants in 2869 participants of a population-based cohort.Five previously identified and 14 novel miRNAs were associated with cognitive domains. Eleven of these were also associated with cortical thickness and two with hippocampal volume. Multi-omics analysis showed that certain identified miRNAs were genetically influenced and regulated genes in pathways like neurogenesis and synapse assembly.We identified miRNAs associated with cognitive domains, brain regions, and neuronal processes affected by aging and neurodegeneration, making them promising candidate blood-based biomarkers or therapeutic targets of subclinical cognitive dysfunction.We investigated the association of blood-derived microRNAs with cognitive domains. Five previously identified and 14 novel microRNAs were associated with cognition. Eleven cognition-related microRNAs were also associated with cortical thickness. Identified microRNAs were linked to genes associated with neuronal functions. Results provide putative biomarkers or therapeutic targets of cognitive aging.
KW  - Humans
KW  - MicroRNAs: genetics
KW  - Male
KW  - Female
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - Cognitive Dysfunction: genetics
KW  - Cognition: physiology
KW  - Brain
KW  - Cohort Studies
KW  - Middle Aged
KW  - Biomarkers: blood
KW  - Hippocampus: pathology
KW  - biomarker (Other)
KW  - cognition (Other)
KW  - cortical thickness (Other)
KW  - miR‐10401‐3p (Other)
KW  - miR‐125b‐5p (Other)
KW  - miR‐128‐3p (Other)
KW  - miR‐134‐5p (Other)
KW  - miR‐192‐5p (Other)
KW  - miR‐215‐5p (Other)
KW  - miR‐4677‐5p (Other)
KW  - miR‐4732‐3p (Other)
KW  - miR‐92a‐3p (Other)
KW  - miR‐92b‐3p (Other)
KW  - microRNA (Other)
KW  - population‐based (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11485070
C6  - pmid:39210637
DO  - DOI:10.1002/alz.14197
UR  - https://pub.dzne.de/record/272572
ER  -