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@ARTICLE{Melas:272572,
      author       = {Melas, Konstantinos and Talevi, Valentina and Imtiaz,
                      Mohammed Aslam and Etteldorf, Rika and Estrada, Santiago and
                      Krüger, Dennis Manfred and Pena-Centeno, Tonatiuh and Aziz,
                      N Ahmad and Fischer, André and Breteler, Monique M B},
      title        = {{B}lood-derived micro{RNA}s are related to cognitive
                      domains in the general population.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {10},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-01193},
      pages        = {7138 - 7159},
      year         = {2024},
      abstract     = {Blood-derived microRNAs (miRNAs) are potential candidates
                      for detecting and preventing subclinical cognitive
                      dysfunction. However, replication of previous findings and
                      identification of novel miRNAs associated with cognitive
                      domains, including their relation to brain structure and the
                      pathways they regulate, are still lacking.We examined
                      blood-derived miRNAs and miRNA co-expression clusters in
                      relation to cognitive domains, structural magnetic resonance
                      imaging measures, target gene expression, and genetic
                      variants in 2869 participants of a population-based
                      cohort.Five previously identified and 14 novel miRNAs were
                      associated with cognitive domains. Eleven of these were also
                      associated with cortical thickness and two with hippocampal
                      volume. Multi-omics analysis showed that certain identified
                      miRNAs were genetically influenced and regulated genes in
                      pathways like neurogenesis and synapse assembly.We
                      identified miRNAs associated with cognitive domains, brain
                      regions, and neuronal processes affected by aging and
                      neurodegeneration, making them promising candidate
                      blood-based biomarkers or therapeutic targets of subclinical
                      cognitive dysfunction.We investigated the association of
                      blood-derived microRNAs with cognitive domains. Five
                      previously identified and 14 novel microRNAs were associated
                      with cognition. Eleven cognition-related microRNAs were also
                      associated with cortical thickness. Identified microRNAs
                      were linked to genes associated with neuronal functions.
                      Results provide putative biomarkers or therapeutic targets
                      of cognitive aging.},
      keywords     = {Humans / MicroRNAs: genetics / Male / Female / Aged /
                      Magnetic Resonance Imaging / Cognitive Dysfunction: genetics
                      / Cognition: physiology / Brain / Cohort Studies / Middle
                      Aged / Biomarkers: blood / Hippocampus: pathology /
                      biomarker (Other) / cognition (Other) / cortical thickness
                      (Other) / miR‐10401‐3p (Other) / miR‐125b‐5p (Other)
                      / miR‐128‐3p (Other) / miR‐134‐5p (Other) /
                      miR‐192‐5p (Other) / miR‐215‐5p (Other) /
                      miR‐4677‐5p (Other) / miR‐4732‐3p (Other) /
                      miR‐92a‐3p (Other) / miR‐92b‐3p (Other) / microRNA
                      (Other) / population‐based (Other)},
      cin          = {AG Breteler / AG Aziz / AG Fischer / Bioinformatics Unit
                      (Göttingen)},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001 / I:(DE-2719)5000071 /
                      I:(DE-2719)1410002 / I:(DE-2719)1440016},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352) / 899 - ohne Topic
                      (POF4-899)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352 /
                      G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11485070},
      pubmed       = {pmid:39210637},
      doi          = {10.1002/alz.14197},
      url          = {https://pub.dzne.de/record/272572},
}