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@ARTICLE{Favila:272575,
      author       = {Favila, Natalia and Capece-Marsico, Jessica and Escribano,
                      Benjamin and Pacheco, Catarina and Bitterman, Yael and
                      Gründemann, Jan and Lüthi, Andreas and Krabbe, Sabine},
      title        = {{H}eterogeneous plasticity of amygdala interneurons in
                      associative learning and extinction},
      journal      = {bioRxiv beta},
      address      = {Cold Spring Harbor},
      publisher    = {Cold Spring Harbor Laboratory, NY},
      reportid     = {DZNE-2024-01196},
      year         = {2024},
      abstract     = {Neural circuits undergo experience-dependent plasticity to
                      form long-lasting memories. Excitatory projection neurons
                      are considered to be the primary neuronal substrate for
                      memory acquisition and storage. However, inhibitory
                      interneurons control the activity of projection neurons in a
                      in a spatially and temporally precise manner, yet their
                      contribution to memory acquisition, storage and expression
                      remains poorly understood. Here, we employ a miniature
                      microscope imaging approach to monitor the activity of large
                      amygdala interneuron populations in freely moving mice
                      during fear learning and extinction at the single cell
                      level. We find that amygdala interneurons display
                      mixed-selectivity and show complex plastic responses at both
                      the ensemble and single neuron level across the acquisition,
                      expression and extinction of aversive memories. In contrast
                      to bidirectional single cell plasticity across distinct fear
                      states, learning-induced changes at the population level
                      occur transiently during conditioning and do not consolidate
                      across days. Examining molecular interneuron subpopulations
                      revealed that disinhibitory vasoactive intestinal peptide
                      (VIP) expressing cells are predominantly activated by high
                      fear states. In contrast, somatostatin (SST) interneurons
                      display a preference for safety cues and thereby suppress
                      excitatory neuron responsiveness. However, responses of
                      individual neurons within the SST and VIP populations are
                      non-uniform, indicating the presence of functional subtypes
                      within classical molecularly-defined interneuron
                      populations. Taken together, we identify complex neuronal
                      plasticity within amygdala interneuron ensembles that goes
                      beyond a passive processing function, suggesting a critical
                      role of inhibitory microcircuit elements for memory
                      selectivity and stability.},
      cin          = {AG Krabbe / AG Gründemann},
      ddc          = {570},
      cid          = {I:(DE-2719)5000059 / I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.09.29.612271},
      url          = {https://pub.dzne.de/record/272575},
}