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037 _ _ |a DZNE-2024-01196
082 _ _ |a 570
100 1 _ |a Favila, Natalia
|0 P:(DE-2719)9001992
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|e First author
245 _ _ |a Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
260 _ _ |a Cold Spring Harbor
|c 2024
|b Cold Spring Harbor Laboratory, NY
336 7 _ |a Preprint
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336 7 _ |a Electronic Article
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336 7 _ |a ARTICLE
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520 _ _ |a Neural circuits undergo experience-dependent plasticity to form long-lasting memories. Excitatory projection neurons are considered to be the primary neuronal substrate for memory acquisition and storage. However, inhibitory interneurons control the activity of projection neurons in a in a spatially and temporally precise manner, yet their contribution to memory acquisition, storage and expression remains poorly understood. Here, we employ a miniature microscope imaging approach to monitor the activity of large amygdala interneuron populations in freely moving mice during fear learning and extinction at the single cell level. We find that amygdala interneurons display mixed-selectivity and show complex plastic responses at both the ensemble and single neuron level across the acquisition, expression and extinction of aversive memories. In contrast to bidirectional single cell plasticity across distinct fear states, learning-induced changes at the population level occur transiently during conditioning and do not consolidate across days. Examining molecular interneuron subpopulations revealed that disinhibitory vasoactive intestinal peptide (VIP) expressing cells are predominantly activated by high fear states. In contrast, somatostatin (SST) interneurons display a preference for safety cues and thereby suppress excitatory neuron responsiveness. However, responses of individual neurons within the SST and VIP populations are non-uniform, indicating the presence of functional subtypes within classical molecularly-defined interneuron populations. Taken together, we identify complex neuronal plasticity within amygdala interneuron ensembles that goes beyond a passive processing function, suggesting a critical role of inhibitory microcircuit elements for memory selectivity and stability.
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700 1 _ |a Capece-Marsico, Jessica
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700 1 _ |a Escribano, Benjamin
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700 1 _ |a Pacheco, Catarina
|0 P:(DE-2719)9001811
|b 3
|u dzne
700 1 _ |a Bitterman, Yael
|0 0000-0002-4153-3888
|b 4
700 1 _ |a Gründemann, Jan
|0 P:(DE-2719)9001219
|b 5
700 1 _ |a Lüthi, Andreas
|0 0000-0002-1859-4252
|b 6
700 1 _ |a Krabbe, Sabine
|0 P:(DE-2719)9001056
|b 7
|e Last author
773 _ _ |a 10.1101/2024.09.29.612271
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|t bioRxiv beta
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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914 1 _ |y 2024
915 _ _ |a OpenAccess
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915 _ _ |a Creative Commons Attribution CC BY 4.0
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920 1 _ |0 I:(DE-2719)5000059
|k AG Krabbe
|l Functional Diversity of Neural Circuits
|x 0
920 1 _ |0 I:(DE-2719)5000069
|k AG Gründemann
|l Neural Circuit Computations
|x 1
980 _ _ |a preprint
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)5000059
980 _ _ |a I:(DE-2719)5000069
980 1 _ |a FullTexts


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