TY  - JOUR
AU  - Pötter-Nerger, Monika
AU  - Löhle, Matthias
AU  - Höglinger, Günter
TI  - Akinetic crisis and withdrawal syndromes: guideline 'Parkinson's disease' of the German Society of Neurology.
JO  - Journal of neurology
VL  - 271
IS  - 10
SN  - 0367-004X
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2024-01202
SP  - 6485 - 6493
PY  - 2024
AB  - The akinetic crisis is a well-known, rare, potentially life-threatening condition in Parkinson's disease with subacute worsening of akinesia, rigidity, fever, impaired consciousness, accompanying vegetative symptoms and transient dopa-resistance. The akinetic crisis was historically supposed to be a 'withdrawal syndrome' in the sense of discontinuation of dopaminergic medication. Recently, other 'withdrawal syndromes' as the specific 'dopamine agonist withdrawal syndrome' or 'deep brain stimulation withdrawal syndrome' have been described as emergency situations with specific subacute symptom constellations. All three conditions require immediate start of the adequate therapy to improve the prognosis. Here, the diagnostic criteria and treatment options of these three acute, severely disabling syndromes will be reported along the current guidelines of the German Parkinson Guideline Group.
KW  - Humans
KW  - Parkinson Disease: drug therapy
KW  - Parkinson Disease: diagnosis
KW  - Parkinson Disease: therapy
KW  - Substance Withdrawal Syndrome: diagnosis
KW  - Germany
KW  - Neurology: standards
KW  - Societies, Medical: standards
KW  - Antiparkinson Agents: therapeutic use
KW  - Antiparkinson Agents: adverse effects
KW  - Deep Brain Stimulation: standards
KW  - Practice Guidelines as Topic: standards
KW  - Akinetic crisis (Other)
KW  - Deep brain stimulation withdrawal syndrome (Other)
KW  - Diagnostic criteria (Other)
KW  - Dopamine agonist withdrawal syndrome (Other)
KW  - German Parkinson Guideline (Other)
KW  - Therapy (Other)
KW  - Antiparkinson Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39192030
C2  - pmc:PMC11447035
DO  - DOI:10.1007/s00415-024-12649-x
UR  - https://pub.dzne.de/record/272581
ER  -