001     272581
005     20250314091251.0
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024 7 _ |a 0340-5354
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024 7 _ |a 1432-1459
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037 _ _ |a DZNE-2024-01202
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100 1 _ |a Pötter-Nerger, Monika
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245 _ _ |a Akinetic crisis and withdrawal syndromes: guideline 'Parkinson's disease' of the German Society of Neurology.
260 _ _ |a Heidelberg
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520 _ _ |a The akinetic crisis is a well-known, rare, potentially life-threatening condition in Parkinson's disease with subacute worsening of akinesia, rigidity, fever, impaired consciousness, accompanying vegetative symptoms and transient dopa-resistance. The akinetic crisis was historically supposed to be a 'withdrawal syndrome' in the sense of discontinuation of dopaminergic medication. Recently, other 'withdrawal syndromes' as the specific 'dopamine agonist withdrawal syndrome' or 'deep brain stimulation withdrawal syndrome' have been described as emergency situations with specific subacute symptom constellations. All three conditions require immediate start of the adequate therapy to improve the prognosis. Here, the diagnostic criteria and treatment options of these three acute, severely disabling syndromes will be reported along the current guidelines of the German Parkinson Guideline Group.
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650 _ 7 |a Akinetic crisis
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650 _ 7 |a Deep brain stimulation withdrawal syndrome
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650 _ 7 |a Diagnostic criteria
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650 _ 7 |a Dopamine agonist withdrawal syndrome
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650 _ 7 |a German Parkinson Guideline
|2 Other
650 _ 7 |a Therapy
|2 Other
650 _ 7 |a Antiparkinson Agents
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Parkinson Disease: drug therapy
|2 MeSH
650 _ 2 |a Parkinson Disease: diagnosis
|2 MeSH
650 _ 2 |a Parkinson Disease: therapy
|2 MeSH
650 _ 2 |a Substance Withdrawal Syndrome: diagnosis
|2 MeSH
650 _ 2 |a Germany
|2 MeSH
650 _ 2 |a Neurology: standards
|2 MeSH
650 _ 2 |a Societies, Medical: standards
|2 MeSH
650 _ 2 |a Antiparkinson Agents: therapeutic use
|2 MeSH
650 _ 2 |a Antiparkinson Agents: adverse effects
|2 MeSH
650 _ 2 |a Deep Brain Stimulation: standards
|2 MeSH
650 _ 2 |a Practice Guidelines as Topic: standards
|2 MeSH
700 1 _ |a Löhle, Matthias
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700 1 _ |a Höglinger, Günter
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700 1 _ |a Group, German Parkinson‘s Guideline
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773 _ _ |a 10.1007/s00415-024-12649-x
|g Vol. 271, no. 10, p. 6485 - 6493
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