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@ARTICLE{VeithSanches:272587,
author = {Veith Sanches, Linda and Greten, Stephan and Doll-Lee,
Johanna and Rogozinski, Sophia Marie and Heine, Johanne and
Krey, Lea and Ulaganathan, Sarana and Jensen, Ida Marie
Louise and Höllerhage, Matthias and Sani, Sam Sadeghi and
Höglinger, Günter U and Wegner, Florian and Klietz,
Martin},
title = {{SEND}-{PD} in {P}arkinsonian {S}yndromes: {R}esults of a
{M}onocentric {C}ross-{S}ectional {S}tudy.},
journal = {Neuropsychiatric disease and treatment},
volume = {20},
issn = {1176-6328},
address = {Albany, Auckland},
publisher = {Dove Medical Press},
reportid = {DZNE-2024-01208},
pages = {1849 - 1859},
year = {2024},
abstract = {Neuropsychiatric symptoms in particular impair
health-related quality of life (QoL) of patients with
Parkinson's disease and atypical Parkinsonian syndromes. For
this reason, various scales have been developed for
detection of neuropsychiatric symptoms, such as the Scale
for evaluation of neuropsychiatric disorders in Parkinson's
disease (SEND-PD).First, the objective of this study was to
explore the interrelation between the SEND-PD and clinical
parameters in patients with Parkinson's disease and thus
confirm its validity. In addition, the applicability in a
well-defined cohort of patients with atypical Parkinsonian
syndromes was investigated for the very first time.A
clinically well-defined cohort of 122 patients with
Parkinson's disease (PD), 55 patients with Progressive
Supranuclear Palsy (PSP) and 33 patients with Multiple
System Atrophy (MSA) were analyzed. First, the SEND-PD was
correlated with established disease-specific scores in
patients with PD. Next, the results of the SEND-PD were
compared between the different Parkinsonian syndromes.The
SEND-PD showed a strong significant correlation with several
scores, especially the UPDRS I (Rho = 0.655) and GDS-15 (Rho
= 0.645). Depressive burden was significantly higher in MSA
patients in comparison to the PD patient cohort (PD, 3.8 ±
3.3; MSA, 5.45 ± 3.87), while PSP patients showed
significantly less psychotic (PD 1.6 ± 2.1; PSP 0.6 ± 0.9)
and impulse control disorders (PD 0.3 ± 1.0; PSP 0.02 ±
0.1).The SEND-PD is a useful, brief and highly applicable
screening tool for neuropsychiatric symptoms in PD, but not
in atypical Parkinsonism, as their unique neuropsychiatric
symptom composition is not fully captured.},
keywords = {Parkinsonian syndromes (Other) / SEND-PD (Other) /
neuropsychiatric symptoms (Other)},
cin = {Clinical Research (Munich) / AG Höglinger},
ddc = {610},
cid = {I:(DE-2719)1111015 / I:(DE-2719)1110002},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39372876},
pmc = {pmc:PMC11453152},
doi = {10.2147/NDT.S474584},
url = {https://pub.dzne.de/record/272587},
}