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@ARTICLE{Schieferstein:272595,
      author       = {Schieferstein, Natalie and Del Toro, Ana and Evangelista,
                      Roberta and Imbrosci, Barbara and Swaminathan, Aarti and
                      Schmitz, Dietmar and Maier, Nikolaus and Kempter, Richard},
      title        = {{P}ropagation of sharp wave-ripple activity in the mouse
                      hippocampal {CA}3 subfield in vitro.},
      journal      = {The journal of physiology},
      volume       = {602},
      number       = {19},
      issn         = {0022-3751},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2024-01216},
      pages        = {5039 - 5059},
      year         = {2024},
      abstract     = {Sharp wave-ripple complexes (SPW-Rs) are spontaneous
                      oscillatory events that characterize hippocampal activity
                      during resting periods and slow-wave sleep. SPW-Rs are
                      related to memory consolidation - the process during which
                      newly acquired memories are transformed into long-lasting
                      memory traces. To test the involvement of SPW-Rs in this
                      process, it is crucial to understand how SPW-Rs originate
                      and propagate throughout the hippocampus. SPW-Rs can
                      originate in CA3, and they typically spread from CA3 to CA1,
                      but little is known about their formation within CA3. To
                      investigate the generation and propagation of SPW-Rs in CA3,
                      we recorded from mouse hippocampal slices using
                      multi-electrode arrays and patch-clamp electrodes. We
                      characterized extracellular and intracellular correlates of
                      SPW-Rs and quantified their propagation along the pyramidal
                      cell layer of CA3. We found that a hippocampal slice can be
                      described by a speed and a direction of propagation of
                      SPW-Rs. The preferred propagation direction was from CA3c
                      (the subfield closer to the dentate gyrus) toward CA3a (the
                      subfield at the boundary to CA2). In patch-clamp recordings
                      from CA3 pyramidal neurons, propagation was estimated
                      separately for excitatory and inhibitory currents associated
                      with SPW-Rs. We found that propagation speed and direction
                      of excitatory and inhibitory currents were correlated. The
                      magnitude of the speed of propagation of SPW-Rs within CA3
                      was consistent with the speed of propagation of action
                      potentials in axons of CA3 principal cells. KEY POINTS:
                      Hippocampal sharp waves are considered important for memory
                      consolidation; therefore, it is of interest to understand
                      the mechanisms of their generation and propagation. Here, we
                      used two different approaches to study the propagation of
                      sharp waves in mouse CA3 in vitro: multi-electrode arrays
                      and multiple single-cell recordings. We find a preferred
                      direction of propagation of sharp waves from CA3c toward
                      CA3a - both in the local field potential and in sharp
                      wave-associated excitatory and inhibitory synaptic activity.
                      The speed of sharp wave propagation is consistent with the
                      speed of action potential propagation along the axons of CA3
                      pyramidal neurons. These new insights into the dynamics of
                      sharp waves in the CA3 network will inform future
                      experiments and theoretical models of sharp-wave generation
                      mechanisms.},
      keywords     = {Animals / CA3 Region, Hippocampal: physiology / Mice /
                      Mice, Inbred C57BL / Male / Pyramidal Cells: physiology /
                      Action Potentials: physiology / Patch-Clamp Techniques /
                      CA3a/CA3b/CA3c subregions (Other) / hippocampus (Other) /
                      mouse (Other) / multi‐electrode array recording (Other) /
                      patch‐clamp recording (Other) / sharp wave‐ripple
                      complexes (Other)},
      cin          = {AG Schmitz},
      ddc          = {610},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39216085},
      doi          = {10.1113/JP285671},
      url          = {https://pub.dzne.de/record/272595},
}