%0 Journal Article
%A Del Tredici, Kelly
%A Schön, Michael
%A Feldengut, Simone
%A Ghebremedhin, Estifanos
%A Kaufman, Sarah K
%A Wiesner, Diana
%A Roselli, Francesco
%A Mayer, Benjamin
%A Amunts, Katrin
%A Braak, Heiko
%T Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer's Disease.
%J Journal of Alzheimer's disease
%V 101
%N 4
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DZNE-2024-01223
%P 1333 - 1353
%D 2024
%X Neuropathologic studies of brains from autopsy series show tau inclusions (pretangles, neuropils threads, neurofibrillary tangles) are detectable more than a decade before amyloid-β (Aβ) deposition in Alzheimer's disease (AD) and develop in a characteristic manner that forms the basis for AD staging. An alternative position views pathological tau without Aβ deposition as a 'primary age-related tauopathy' (PART) rather than prodromal AD. Recently, an early focus of tau inclusions in the Ammon's horn second sector (CA2) with relative sparing of CA1 that occurs before tau inclusions develop in the entorhinal cortex (EC) was proposed as an additional feature of PART.To test the 'definite PART' hypothesis.We used AT8-immunohistochemistry in 100μm sections to examine the EC, transentorhinal cortex (TRE), and Ammon's horn in 325 brains with tau inclusions lacking Aβ deposits (average age at death 66.7 years for females, 66.4 years for males).100
%K Humans
%K Alzheimer Disease: pathology
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: genetics
%K Female
%K Aged
%K Male
%K Tauopathies: pathology
%K Tauopathies: metabolism
%K tau Proteins: metabolism
%K Aged, 80 and over
%K Entorhinal Cortex: pathology
%K Entorhinal Cortex: metabolism
%K Middle Aged
%K CA2 Region, Hippocampal: pathology
%K CA2 Region, Hippocampal: metabolism
%K Inclusion Bodies: pathology
%K Inclusion Bodies: metabolism
%K Neurofibrillary Tangles: pathology
%K Neurofibrillary Tangles: metabolism
%K Aging: pathology
%K Aging: metabolism
%K APOE (Other)
%K Alzheimer’s disease (Other)
%K Ammon’s horn (Other)
%K CA2 (Other)
%K PART hypothesis (Other)
%K entorhinal cortex (Other)
%K neurofibrillary tangles (Other)
%K pretangles (Other)
%K tau seeding (Other)
%K tractus perforans (Other)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39302368
%R 10.3233/JAD-240483
%U https://pub.dzne.de/record/272672