TY  - JOUR
AU  - Del Tredici, Kelly
AU  - Schön, Michael
AU  - Feldengut, Simone
AU  - Ghebremedhin, Estifanos
AU  - Kaufman, Sarah K
AU  - Wiesner, Diana
AU  - Roselli, Francesco
AU  - Mayer, Benjamin
AU  - Amunts, Katrin
AU  - Braak, Heiko
TI  - Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer's Disease.
JO  - Journal of Alzheimer's disease
VL  - 101
IS  - 4
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2024-01223
SP  - 1333 - 1353
PY  - 2024
AB  - Neuropathologic studies of brains from autopsy series show tau inclusions (pretangles, neuropils threads, neurofibrillary tangles) are detectable more than a decade before amyloid-β (Aβ) deposition in Alzheimer's disease (AD) and develop in a characteristic manner that forms the basis for AD staging. An alternative position views pathological tau without Aβ deposition as a 'primary age-related tauopathy' (PART) rather than prodromal AD. Recently, an early focus of tau inclusions in the Ammon's horn second sector (CA2) with relative sparing of CA1 that occurs before tau inclusions develop in the entorhinal cortex (EC) was proposed as an additional feature of PART.To test the 'definite PART' hypothesis.We used AT8-immunohistochemistry in 100μm sections to examine the EC, transentorhinal cortex (TRE), and Ammon's horn in 325 brains with tau inclusions lacking Aβ deposits (average age at death 66.7 years for females, 66.4 years for males).100
KW  - Humans
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: genetics
KW  - Female
KW  - Aged
KW  - Male
KW  - Tauopathies: pathology
KW  - Tauopathies: metabolism
KW  - tau Proteins: metabolism
KW  - Aged, 80 and over
KW  - Entorhinal Cortex: pathology
KW  - Entorhinal Cortex: metabolism
KW  - Middle Aged
KW  - CA2 Region, Hippocampal: pathology
KW  - CA2 Region, Hippocampal: metabolism
KW  - Inclusion Bodies: pathology
KW  - Inclusion Bodies: metabolism
KW  - Neurofibrillary Tangles: pathology
KW  - Neurofibrillary Tangles: metabolism
KW  - Aging: pathology
KW  - Aging: metabolism
KW  - APOE (Other)
KW  - Alzheimer’s disease (Other)
KW  - Ammon’s horn (Other)
KW  - CA2 (Other)
KW  - PART hypothesis (Other)
KW  - entorhinal cortex (Other)
KW  - neurofibrillary tangles (Other)
KW  - pretangles (Other)
KW  - tau seeding (Other)
KW  - tractus perforans (Other)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39302368
DO  - DOI:10.3233/JAD-240483
UR  - https://pub.dzne.de/record/272672
ER  -