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000272724 0247_ $$2doi$$a10.1158/1078-0432.CCR-24-1563
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000272724 037__ $$aDZNE-2024-01226
000272724 041__ $$aEnglish
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000272724 1001_ $$00009-0007-6158-319X$$aBartos, Laura M$$b0
000272724 245__ $$aRemote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.
000272724 260__ $$aPhiladelphia, Pa. [u.a.]$$bAACR$$c2024
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000272724 520__ $$aCurrent therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in the brain of patients with glioblastoma have been described. However, the impact and molecular signature of neuroinflammation distant of the primary tumor site have not yet been thoroughly elucidated.We performed translocator protein (TSPO)-PET in patients with newly diagnosed glioblastoma (n = 41), astrocytoma WHO grade 2 (n = 7), and healthy controls (n = 20) and compared TSPO-PET signals of the non-lesion (i.e., contralateral) hemisphere. Back-translation into syngeneic SB28 glioblastoma mice was used to characterize Pet alterations on a cellular level. Ultimately, multiplex gene expression analyses served to profile immune cells in remote brain.Our study revealed elevated TSPO-PET signals in contralateral hemispheres of patients with newly diagnosed glioblastoma compared to healthy controls. Contralateral TSPO was associated with persisting epileptic seizures and shorter overall survival independent of the tumor phenotype. Back-translation into syngeneic glioblastoma mice pinpointed myeloid cells as the predominant source of contralateral TSPO-PET signal increases and identified a complex immune signature characterized by myeloid cell activation and immunosuppression in distant brain regions.Neuroinflammation within the contralateral hemisphere can be detected with TSPO-PET imaging and associates with poor outcome in patients with newly diagnosed glioblastoma. The molecular signature of remote neuroinflammation promotes the evaluation of immunomodulatory strategies in patients with detrimental whole brain inflammation as reflected by high TSPO expression.
000272724 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
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000272724 650_7 $$2NLM Chemicals$$aReceptors, GABA
000272724 650_7 $$2NLM Chemicals$$aTSPO protein, human
000272724 650_2 $$2MeSH$$aGlioblastoma: pathology
000272724 650_2 $$2MeSH$$aGlioblastoma: genetics
000272724 650_2 $$2MeSH$$aGlioblastoma: metabolism
000272724 650_2 $$2MeSH$$aGlioblastoma: diagnosis
000272724 650_2 $$2MeSH$$aGlioblastoma: mortality
000272724 650_2 $$2MeSH$$aHumans
000272724 650_2 $$2MeSH$$aAnimals
000272724 650_2 $$2MeSH$$aMice
000272724 650_2 $$2MeSH$$aReceptors, GABA: metabolism
000272724 650_2 $$2MeSH$$aReceptors, GABA: genetics
000272724 650_2 $$2MeSH$$aMale
000272724 650_2 $$2MeSH$$aFemale
000272724 650_2 $$2MeSH$$aMiddle Aged
000272724 650_2 $$2MeSH$$aBrain Neoplasms: pathology
000272724 650_2 $$2MeSH$$aBrain Neoplasms: genetics
000272724 650_2 $$2MeSH$$aBrain Neoplasms: metabolism
000272724 650_2 $$2MeSH$$aBrain Neoplasms: diagnosis
000272724 650_2 $$2MeSH$$aNeuroinflammatory Diseases: pathology
000272724 650_2 $$2MeSH$$aNeuroinflammatory Diseases: etiology
000272724 650_2 $$2MeSH$$aNeuroinflammatory Diseases: diagnosis
000272724 650_2 $$2MeSH$$aAdult
000272724 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000272724 650_2 $$2MeSH$$aAged
000272724 650_2 $$2MeSH$$aPrognosis
000272724 650_2 $$2MeSH$$aTumor Microenvironment: immunology
000272724 650_2 $$2MeSH$$aDisease Models, Animal
000272724 7001_ $$00000-0003-2914-3649$$aQuach, Stefanie$$b1
000272724 7001_ $$0P:(DE-2719)9002392$$aZenatti, Valerio$$b2$$udzne
000272724 7001_ $$00000-0001-6864-3369$$aKirchleitner, Sabrina V$$b3
000272724 7001_ $$00000-0002-8539-8745$$aBlobner, Jens$$b4
000272724 7001_ $$0P:(DE-2719)9001653$$aWind, Karin$$b5$$udzne
000272724 7001_ $$00000-0002-0672-681X$$aKolabas, Zeynep Ilgin$$b6
000272724 7001_ $$00009-0000-3035-3155$$aUlukaya, Selin$$b7
000272724 7001_ $$00000-0002-9566-8438$$aHolzgreve, Adrien$$b8
000272724 7001_ $$00000-0002-3876-8854$$aRuf, Viktoria C$$b9
000272724 7001_ $$0P:(DE-2719)9002311$$aKunze, Lea$$b10$$udzne
000272724 7001_ $$00009-0007-3543-5329$$aKunte, Sebastian T$$b11
000272724 7001_ $$00009-0006-9074-3474$$aHoermann, Leonie$$b12
000272724 7001_ $$00009-0007-3195-0980$$aHärtel, Marlies$$b13
000272724 7001_ $$00009-0002-1872-128X$$aPark, Ha Eun$$b14
000272724 7001_ $$00009-0001-7729-2182$$aGroß, Mattes$$b15
000272724 7001_ $$00000-0001-9736-2283$$aFranzmeier, Nicolai$$b16
000272724 7001_ $$0P:(DE-2719)9001654$$aZatcepin, Artem$$b17
000272724 7001_ $$00000-0001-8765-1276$$aZounek, Adrian$$b18
000272724 7001_ $$00000-0002-2084-5858$$aKaiser, Lena$$b19
000272724 7001_ $$00000-0002-3742-2982$$aRiemenschneider, Markus J$$b20
000272724 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b21
000272724 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b22$$udzne
000272724 7001_ $$00000-0003-0325-4674$$aStöcklein, Sophia$$b23
000272724 7001_ $$00000-0002-5321-4817$$aZiegler, Sibylle$$b24
000272724 7001_ $$0P:(DE-2719)2810441$$aHerms, Jochen$$b25$$udzne
000272724 7001_ $$00000-0001-5163-5100$$aErtürk, Ali$$b26
000272724 7001_ $$00009-0004-1756-423X$$aTonn, Joerg C$$b27
000272724 7001_ $$00000-0003-0011-5281$$aThon, Niklas$$b28
000272724 7001_ $$00000-0002-6634-0927$$avon Baumgarten, Louisa$$b29
000272724 7001_ $$0P:(DE-2719)9001400$$aPrestel, Matthias$$b30$$udzne
000272724 7001_ $$0P:(DE-2719)2442036$$aTahirovic, Sabina$$b31
000272724 7001_ $$00000-0003-0953-7624$$aAlbert, Nathalie L$$b32
000272724 7001_ $$0P:(DE-2719)9001539$$aBrendel, Matthias$$b33$$eLast author
000272724 773__ $$0PERI:(DE-600)2036787-9$$a10.1158/1078-0432.CCR-24-1563$$gVol. 30, no. 20, p. 4618 - 4634$$n20$$p4618 - 4634$$tClinical cancer research$$v30$$x1078-0432$$y2024
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