TY  - JOUR
AU  - Junker, Johanna
AU  - Lange, Lara Mariah
AU  - Vollstedt, Eva-Juliane
AU  - Roopnarain, Karisha
AU  - Doquenia, Maria Leila M
AU  - Annuar, Azlina Ahmad
AU  - Avenali, Micol
AU  - Bardien, Soraya
AU  - Bahr, Natascha
AU  - Ellis, Melina
AU  - Galandra, Caterina
AU  - Gasser, Thomas
AU  - Heutink, Peter
AU  - Illarionova, Anastasia
AU  - Kanana, Yuliia
AU  - Keller Sarmiento, Ignacio J
AU  - Kumar, Kishore R
AU  - Lim, Shen-Yang
AU  - Madoev, Harutyun
AU  - Mata, Ignacio F
AU  - Mencacci, Niccolò E
AU  - Nalls, Mike A
AU  - Padmanabhan, Shalini
AU  - Shambetova, Cholpon
AU  - Solle, J. C.
AU  - Tan, Ai-Huey
AU  - Trinh, Joanne
AU  - Valente, Enza Maria
AU  - Singleton, Andrew
AU  - Blauwendraat, Cornelis
AU  - Lohmann, Katja
AU  - Fang, Zih-Hua
AU  - Klein, Christine
TI  - Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale.
JO  - Movement disorders
VL  - 39
IS  - 10
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2024-01239
SP  - 1868 - 1873
PY  - 2024
AB  - Until recently, about three-quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype-phenotype relationships at a global scale.To identify the multi-ancestry spectrum of monogenic PD.The first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global Monogenic PD Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD-causing genes. In contrast, the Global Parkinson's Genetics Program's Monogenic Network took a different approach by targeting PD centers underrepresented or not yet represented in the medical literature.In this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi-ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD.This effort demonstrates the value of future research based on team science approaches to generate comprehensive and globally relevant results. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
KW  - Humans
KW  - Parkinson Disease: genetics
KW  - Parkinson Disease: therapy
KW  - Genetic Predisposition to Disease
KW  - Genetic Association Studies: methods
KW  - GP2 (Other)
KW  - MJFF GMPD (Other)
KW  - Parkinson's disease (Other)
KW  - monogenic Parkinson's disease (Other)
KW  - parkinsonism (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39076159
DO  - DOI:10.1002/mds.29925
UR  - https://pub.dzne.de/record/272821
ER  -