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@ARTICLE{Junker:272821,
author = {Junker, Johanna and Lange, Lara Mariah and Vollstedt,
Eva-Juliane and Roopnarain, Karisha and Doquenia, Maria
Leila M and Annuar, Azlina Ahmad and Avenali, Micol and
Bardien, Soraya and Bahr, Natascha and Ellis, Melina and
Galandra, Caterina and Gasser, Thomas and Heutink, Peter and
Illarionova, Anastasia and Kanana, Yuliia and Keller
Sarmiento, Ignacio J and Kumar, Kishore R and Lim, Shen-Yang
and Madoev, Harutyun and Mata, Ignacio F and Mencacci,
Niccolò E and Nalls, Mike A and Padmanabhan, Shalini and
Shambetova, Cholpon and Solle, J. C. and Tan, Ai-Huey and
Trinh, Joanne and Valente, Enza Maria and Singleton, Andrew
and Blauwendraat, Cornelis and Lohmann, Katja and Fang,
Zih-Hua and Klein, Christine},
collaboration = {Program, Global Parkinson's Genetics},
othercontributors = {Junker, Johanna and Lange, Lara Mariah and Vollstedt,
Eva-Juliane and Roopnarain, Karisha and Doquenia, Maria
Leila M and Annuar, Azlina Ahmad and Avenali, Micol and
Bardien, Soraya and Bahr, Natascha and Ellis, Melina and
Galandra, Caterina and Gasser, Thomas and Heutink, Peter and
Illarionova, Anastasia and Kanana, Yuliia and Keller,
Ignacio J and Kumar, Kishore R and Lim, Shen-Yang and
Madoev, Harutyun and Mata, Ignacio F and Mencacci, Niccolò
E and Nalls's, Mike A and Padmanabhan, Shalini and
Shambetova, Cholpon and Solle, J. and Tan, Ai-Huey and
Trinh, Joanne and Valente, Enza Maria and Singleton, Andrew
and Blauwendraat, Cornelis and Lohmann, Katja and Fang,
Zih-Hua and Klein, Christine},
title = {{T}eam {S}cience {A}pproaches to {U}nravel {M}onogenic
{P}arkinson's {D}isease on a {G}lobal {S}cale.},
journal = {Movement disorders},
volume = {39},
number = {10},
issn = {0885-3185},
address = {New York, NY},
publisher = {Wiley},
reportid = {DZNE-2024-01239},
pages = {1868 - 1873},
year = {2024},
abstract = {Until recently, about three-quarters of all monogenic
Parkinson's disease (PD) studies were performed in
European/White ancestry, thereby severely limiting our
insights into genotype-phenotype relationships at a global
scale.To identify the multi-ancestry spectrum of monogenic
PD.The first systematic approach to embrace monogenic PD
worldwide, The Michael J. Fox Foundation Global Monogenic PD
Project, contacted authors of publications reporting
individuals carrying pathogenic variants in known PD-causing
genes. In contrast, the Global Parkinson's Genetics
Program's Monogenic Network took a different approach by
targeting PD centers underrepresented or not yet represented
in the medical literature.In this article, we describe
combining both efforts in a merger project resulting in a
global monogenic PD cohort with the buildup of a sustainable
infrastructure to identify the multi-ancestry spectrum of
monogenic PD and enable studies of factors modifying
penetrance and expressivity of monogenic PD.This effort
demonstrates the value of future research based on team
science approaches to generate comprehensive and globally
relevant results. © 2024 The Author(s). Movement Disorders
published by Wiley Periodicals LLC on behalf of
International Parkinson and Movement Disorder Society.},
keywords = {Humans / Parkinson Disease: genetics / Parkinson Disease:
therapy / Genetic Predisposition to Disease / Genetic
Association Studies: methods / GP2 (Other) / MJFF GMPD
(Other) / Parkinson's disease (Other) / monogenic
Parkinson's disease (Other) / parkinsonism (Other)},
cin = {AG Gasser / AG Heutink / ICRU},
ddc = {610},
cid = {I:(DE-2719)1210000 / I:(DE-2719)1210002 /
I:(DE-2719)1240005},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 354 -
Disease Prevention and Healthy Aging (POF4-354) / 899 - ohne
Topic (POF4-899)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354 /
G:(DE-HGF)POF4-899},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39076159},
doi = {10.1002/mds.29925},
url = {https://pub.dzne.de/record/272821},
}