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@ARTICLE{Hglinger:272837,
      author       = {Höglinger, Günter U and Lang, Anthony E},
      title        = {{T}he why and how of the {S}yn{N}er{G}e criteria of
                      {P}arkinson´s disease.},
      journal      = {Journal of neural transmission},
      volume       = {131},
      number       = {10},
      issn         = {0375-9245},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {DZNE-2024-01255},
      pages        = {1149 - 1154},
      year         = {2024},
      abstract     = {In pursuit of early therapeutic interventions for
                      Parkinson's disease, the proposed SynNeurGe classification
                      system integrates α-synuclein pathology (S),
                      neurodegeneration evidence (N), and pathogenic gene variants
                      (G). This approach aims to address the disease's complexity
                      and biological diversity. It suggests categorizing patients
                      based on the presence or absence of α-synuclein pathology
                      in tissues or cerebrospinal fluid, neurodegeneration
                      indicators from specific imaging techniques, and
                      identification of pathogenic gene variants associated with
                      Parkinson's disease. The proposed system emphasizes the
                      future need for precision medicine and aims to facilitate
                      both basic and clinical research toward disease-modifying
                      therapies. However, the authors stress that initial
                      implementation should be confined to research settings,
                      considering ethical implications and current limitations.
                      Prospective validation of these criteria is deemed necessary
                      to ensure their efficacy and ethical application in clinical
                      practice.},
      subtyp        = {Review Article},
      keywords     = {Humans / Parkinson Disease: diagnosis / Parkinson Disease:
                      genetics / alpha-Synuclein: metabolism / alpha-Synuclein:
                      cerebrospinal fluid / Biological definition (Other) /
                      Genetics (Other) / Neurodegeneration (Other) / Parkinson’s
                      disease (Other) / Synuclein (Other) / alpha-Synuclein (NLM
                      Chemicals)},
      cin          = {AG Höglinger / Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1110002 / I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38916622},
      pmc          = {pmc:PMC11489162},
      doi          = {10.1007/s00702-024-02797-9},
      url          = {https://pub.dzne.de/record/272837},
}