TY  - JOUR
AU  - Jensen, Ida Marie Louise
AU  - Heine, Johanne
AU  - Ruf, Viktoria C
AU  - Compta, Yaroslau
AU  - Porcel, Laura Molina
AU  - Troakes, Claire
AU  - Vamanu, Albert
AU  - Downes, Sophia
AU  - Irwin, David
AU  - Cohen, Jesse
AU  - Lee, Edward B
AU  - Nilsson, Christer
AU  - Englund, Elisabet
AU  - Nemati, Mojtaba
AU  - Katzdobler, Sabrina
AU  - Levin, Johannes
AU  - Pantelyat, Alex
AU  - Seemiller, Joseph
AU  - Berger, Stephen
AU  - van Swieten, John
AU  - Dopper, Elise
AU  - Rozenmuller, Annemieke
AU  - Kovacs, Gabor G
AU  - Bendahan, Nathaniel
AU  - Lang, Anthony E
AU  - Herms, Jochen
AU  - Höglinger, Günter
AU  - Hopfner, Franziska
TI  - Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria.
JO  - Movement disorders
VL  - 39
IS  - 9
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2024-01270
SP  - 1514 - 1522
PY  - 2024
AB  - Multiple system atrophy is a neurodegenerative disease with α-synuclein aggregation in glial cytoplasmic inclusions, leading to dysautonomia, parkinsonism, and cerebellar ataxia.The aim of this study was to validate the accuracy of the International Parkinson and Movement Disorder Society Multiple System Atrophy clinical diagnostic criteria, particularly considering the impact of the newly introduced brain magnetic resonance imaging (MRI) markers.Diagnostic accuracy of the clinical diagnostic criteria for multiple system atrophy was estimated retrospectively in autopsy-confirmed patients with multiple system atrophy, Parkinson's disease, progressive supranuclear palsy, and corticobasal degeneration.We identified a total of 240 patients. Sensitivity of the clinically probable criteria was moderate at symptom onset but improved with disease duration (year 1: 9
KW  - Humans
KW  - Multiple System Atrophy: diagnostic imaging
KW  - Multiple System Atrophy: diagnosis
KW  - Female
KW  - Male
KW  - Aged
KW  - Middle Aged
KW  - Parkinson Disease: diagnostic imaging
KW  - Parkinson Disease: diagnosis
KW  - Magnetic Resonance Imaging: standards
KW  - Magnetic Resonance Imaging: methods
KW  - Retrospective Studies
KW  - Supranuclear Palsy, Progressive: diagnostic imaging
KW  - Sensitivity and Specificity
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Aged, 80 and over
KW  - MRI (Other)
KW  - autopsy‐confirmed (Other)
KW  - brain magnetic resonance imaging (Other)
KW  - multiple system atrophy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38847384
DO  - DOI:10.1002/mds.29879
UR  - https://pub.dzne.de/record/272852
ER  -