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@ARTICLE{Jensen:272852,
      author       = {Jensen, Ida Marie Louise and Heine, Johanne and Ruf,
                      Viktoria C and Compta, Yaroslau and Porcel, Laura Molina and
                      Troakes, Claire and Vamanu, Albert and Downes, Sophia and
                      Irwin, David and Cohen, Jesse and Lee, Edward B and Nilsson,
                      Christer and Englund, Elisabet and Nemati, Mojtaba and
                      Katzdobler, Sabrina and Levin, Johannes and Pantelyat, Alex
                      and Seemiller, Joseph and Berger, Stephen and van Swieten,
                      John and Dopper, Elise and Rozenmuller, Annemieke and
                      Kovacs, Gabor G and Bendahan, Nathaniel and Lang, Anthony E
                      and Herms, Jochen and Höglinger, Günter and Hopfner,
                      Franziska},
      title        = {{I}mpact of {M}agnetic {R}esonance {I}maging {M}arkers on
                      the {D}iagnostic {P}erformance of the {I}nternational
                      {P}arkinson and {M}ovement {D}isorder {S}ociety {M}ultiple
                      {S}ystem {A}trophy {C}riteria.},
      journal      = {Movement disorders},
      volume       = {39},
      number       = {9},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-01270},
      pages        = {1514 - 1522},
      year         = {2024},
      abstract     = {Multiple system atrophy is a neurodegenerative disease with
                      α-synuclein aggregation in glial cytoplasmic inclusions,
                      leading to dysautonomia, parkinsonism, and cerebellar
                      ataxia.The aim of this study was to validate the accuracy of
                      the International Parkinson and Movement Disorder Society
                      Multiple System Atrophy clinical diagnostic criteria,
                      particularly considering the impact of the newly introduced
                      brain magnetic resonance imaging (MRI) markers.Diagnostic
                      accuracy of the clinical diagnostic criteria for multiple
                      system atrophy was estimated retrospectively in
                      autopsy-confirmed patients with multiple system atrophy,
                      Parkinson's disease, progressive supranuclear palsy, and
                      corticobasal degeneration.We identified a total of 240
                      patients. Sensitivity of the clinically probable criteria
                      was moderate at symptom onset but improved with disease
                      duration (year 1: $9\%,$ year 3: $39\%,$ final ante mortem
                      record: $77\%),$ whereas their specificity remained
                      consistently high $(99\%-100\%$ throughout). Sensitivity of
                      the clinically established criteria was low during the first
                      3 years $(1\%-9\%),$ with mild improvement at the final ante
                      mortem record $(22\%),$ whereas specificity remained high
                      $(99\%-100\%$ throughout). When MRI features were excluded
                      from the clinically established criteria, their sensitivity
                      increased considerably (year 1: $3\%,$ year 3: $22\%,$ final
                      ante mortem record: $48\%),$ and their specificity was not
                      compromised $(99\%-100\%$ throughout).The International
                      Parkinson and Movement Disorder Society multiple system
                      atrophy diagnostic criteria showed consistently high
                      specificity and low to moderate sensitivity throughout the
                      disease course. The MRI markers for the clinically
                      established criteria reduced their sensitivity without
                      improving specificity. Combining clinically probable and
                      clinically established criteria, but disregarding MRI
                      features, yielded the best sensitivity with excellent
                      specificity and may be most appropriate to select patients
                      for therapeutic trials. © 2024 The Author(s). Movement
                      Disorders published by Wiley Periodicals LLC on behalf of
                      International Parkinson and Movement Disorder Society.},
      keywords     = {Humans / Multiple System Atrophy: diagnostic imaging /
                      Multiple System Atrophy: diagnosis / Female / Male / Aged /
                      Middle Aged / Parkinson Disease: diagnostic imaging /
                      Parkinson Disease: diagnosis / Magnetic Resonance Imaging:
                      standards / Magnetic Resonance Imaging: methods /
                      Retrospective Studies / Supranuclear Palsy, Progressive:
                      diagnostic imaging / Sensitivity and Specificity / Brain:
                      diagnostic imaging / Brain: pathology / Aged, 80 and over /
                      MRI (Other) / autopsy‐confirmed (Other) / brain magnetic
                      resonance imaging (Other) / multiple system atrophy (Other)},
      cin          = {AG Höglinger / AG Herms / Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1110002 / I:(DE-2719)1110001 /
                      I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38847384},
      doi          = {10.1002/mds.29879},
      url          = {https://pub.dzne.de/record/272852},
}