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@INBOOK{Groppa:272870,
      author       = {Gubinelli, Francesco and Salazar, Jose M. and Kaspar,
                      Janina and Ortiz, Irene Santisteban and Schafer, Simon T.
                      and Burbulla, Lena F.},
      editor       = {Groppa, Sergiu and Schneider, Susanne A.},
      title        = {{T}ranslational {V}iew on {T}herapeutic {S}trategies and
                      {U}pcoming {I}ssues: {S}tem {C}ell and {B}rain {O}rganoid
                      {A}pproaches for {P}arkinson’s {D}isease {T}herapy},
      volume       = {213},
      address      = {New York, NY},
      publisher    = {Springer US},
      reportid     = {DZNE-2024-01287},
      isbn         = {978-1-0716-4082-1 (print)},
      series       = {Neuromethods},
      pages        = {241 - 275},
      year         = {2025},
      comment      = {Translational Methods for Parkinson’s Disease and
                      Atypical Parkinsonism Research / Groppa, Sergiu (Editor) ;
                      New York, NY : Springer US, 2025, Chapter 17 ; ISSN:
                      0893-2336=1940-6045 ; ISBN:
                      978-1-0716-4082-1=978-1-0716-4083-8 ;
                      doi:10.1007/978-1-0716-4083-8},
      booktitle     = {Translational Methods for
                       Parkinson’s Disease and Atypical
                       Parkinsonism Research / Groppa, Sergiu
                       (Editor) ; New York, NY : Springer US,
                       2025, Chapter 17 ; ISSN:
                       0893-2336=1940-6045 ; ISBN:
                       978-1-0716-4082-1=978-1-0716-4083-8 ;
                       doi:10.1007/978-1-0716-4083-8},
      abstract     = {There are currently no disease-modifying therapies for
                      Parkinson’s disease (PD), and the available therapies only
                      relieve the symptoms and not disease progression. Cell
                      replacement therapy to restore the degenerating neurons is a
                      promising approach to treating advanced stages of PD. The
                      idea behind cell therapy dates back to the 1970s, when the
                      first transplantation of fetal ventral mesencephalic tissue
                      was performed on neurotoxic animal models of PD and showed
                      promising motor recovery and graft survival. Based on this
                      early proof of concept, several other cell types from
                      different sources—e.g., embryonic stem cells or induced
                      pluripotent stem cells—were tested and used in several
                      preclinical studies, leading to transplantation into a small
                      number of human subjects. After proving the safety of the
                      method and the overall positive clinical outcome, several
                      clinical trials were organized in Europe, in the United
                      States, and in the rest of the world. In this chapter, we
                      describe the story of modern stem cell-based clinical trials
                      for the treatment of PD and highlight the successes and
                      limitations of these approaches as well as the key
                      discoveries associated with it. Part of the chapter is also
                      dedicated to the use of brain organoids as a new promising
                      interface between in vitro and in vivo models, which could
                      lead to the development of novel disease-relevant insights
                      and new promising therapeutic avenues in the near future.},
      cin          = {AG Burbulla},
      ddc          = {610},
      cid          = {I:(DE-2719)5000074},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1007/978-1-0716-4083-8_17},
      url          = {https://pub.dzne.de/record/272870},
}